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Megalis Medication Information Leaflet
Megalis, containing the active ingredient tadalafil, is primarily prescribed for the treatment of erectile dysfunction (ED) in adult males. It is also prescribed to alleviate symptoms of benign prostatic hyperplasia (BPH).
Megalis belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors. It works by increasing blood flow to the penis during sexual stimulation, allowing the patient to achieve and maintain an erection.
Tadalafil, the generic compound of Megalis, is available in the UK under various brand names and as generic medication.
Megalis, containing tadalafil, is approved in multiple countries worldwide for the treatment of ED and BPH. Check with the respective regulatory authorities for specific approval details.
Known Alternatives in UK
In the UK, there are alternative medications available for the treatment of ED and BPH. Your healthcare provider can provide information on potential alternatives, including other PDE5 inhibitors or BPH medications.
Megalis is clinically used to improve erectile function and reduce urinary symptoms associated with BPH.
Spectrum Of Activity
Megalis primarily acts on the erectile tissue of the penis and the smooth muscle of the prostate and bladder. It selectively inhibits PDE5, leading to increased levels of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum, promoting relaxation and vasodilation of blood vessels within these tissues.
Megalis can interact with various medications such as nitrates, alpha-blockers, antihypertensives, antifungals, and HIV protease inhibitors. It is crucial to inform the healthcare provider about all medications, including prescription, over-the-counter, and herbal supplements, to avoid potential drug interactions.
Dosage and Directions
The recommended starting dose for Megalis is 10 mg, taken before anticipated sexual activity. The dose may be adjusted based on individual response. It can be taken with or without food. The maximum recommended dosing frequency is once per day.
Contraindications and Precautions
Megalis is contraindicated in individuals with a known hypersensitivity to tadalafil and in those taking nitrate medications. It should be used with caution in individuals with cardiovascular disease, liver or kidney impairment, and anatomical penile deformities.
Possible side effect
Common side effects of Megalis may include headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. It is important to seek medical attention if any side effects persist or worsen.
Missed dose and Overdose
Megalis is not intended for daily use. If a dose is missed, it can be taken as soon as remembered, prior to sexual activity. Do not take more than the recommended dose. In case of overdose, seek immediate medical attention.
Megalis should be stored at room temperature, away from moisture and heat. Keep it out of the reach of children and pets.
Known Non-standard Use
Tadalafil, the active ingredient in Megalis, has been investigated for potential non-standard uses beyond ED and BPH, including pulmonary arterial hypertension and exercise-induced pulmonary hemorrhage (EIPH) in racehorses.
Special caution should be exercised while using Megalis in patients with existing cardiovascular conditions, as sexual activity poses a potential risk to these patients.
Patients should be educated about the potential for interaction with nitrates and should be advised to seek immediate medical attention for any prolonged or painful erection, lasting 4 hours or more.
Breastfeeding and Pregnancy
Megalis is not indicated for use in women. It is not recommended for use during pregnancy unless the benefits outweigh the potential risks. Tadalafil may pass into breast milk, and its effects on nursing infants are not well-established.
The use of Megalis may be associated with risks, including interactions with other medications, potential side effects, and risks in certain patient populations. Patients should be monitored for adverse effects and should seek medical advice for any concerns.
What is Megalis used for?
Megalis, containing tadalafil, is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hyperplasia (enlarged prostate).
How should I take Megalis?
Take Megalis as directed by your doctor. Do not take more than once a day. It can be taken with or without food.
What are the potential side effects of Megalis?
Common side effects may include headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. Seek medical help if you experience vision or hearing loss or prolonged erection.
Can I take Megalis with other medications?
It is important to inform your doctor about all medications you are taking, including prescription, over-the-counter, vitamins and herbal supplements, to avoid potential interactions with Megalis.
How long does Megalis last?
The effects of Megalis can last for up to 36 hours, enabling a man to be sexually active at a moment’s notice.
Is Megalis safe for everyone?
Megalis may not be suitable for everyone, especially those with certain medical conditions or taking specific medications. Consult with your doctor to determine if Megalis is safe for you.
What should I do if I miss a dose of Megalis?
Megalis is taken as needed, so there is no need to worry about missing a dose.
Is Megalis addictive?
No, Megalis is not addictive.
Can women take Megalis?
Megalis is not indicated for use by women and should not be taken by women or children under 18 years of age.
What is the difference between Megalis and other similar medications?
The main difference between Megalis (tadalafil) and other similar medications is the duration of action, with Megalis providing the longest duration of effectiveness.
Can I drink alcohol while taking Megalis?
Alcohol consumption should be limited while taking Megalis, as excessive alcohol can increase the risk of side effects such as dizziness, headache, and low blood pressure.
How quickly does Megalis work?
Megalis typically starts working within 30 minutes to an hour after taking the medication.
Can I drive after taking Megalis?
Megalis may cause dizziness and affect vision. It is important to assess your individual response to the medication before driving or operating machinery.
What should I do in case of an overdose?
In case of an overdose, seek immediate medical attention or contact a Poison Control Center.
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