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Vaseretic

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Vaseretic (enalapril and hydrochlorothiazide) is a combination therapy for the treatment of hypertension. It pairs an ACE inhibitor with a diuretic to lower blood pressure more effectively than either component alone. This combination facilitates better blood flow and reduces the workload on the heart, benefiting long-term cardiovascular health.


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In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Enalapril, Hydrochlorothiazide
Reference Brand
Vaseretic
Manufacturer
Merck & Co.
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Blood Pressure Control
Product Category
Antihypertensive Combination
Pharmacological Class
ACE Inhibitor, Thiazide Diuretic
Manufacturer Description
A combination pill used when a single medicine is not enough to control high blood pressure.
Mechanism of Action
Enalapril relaxes blood vessels, while Hydrochlorothiazide helps the kidneys remove extra salt and water. Together, they reduce blood pressure and heart workload.
Route of Administration
Oral
Onset Time
1-2 hours
Duration
24 hours
Contraindications
Angioedema, Renal artery stenosis, Anuria, Sulfa drug allergy
Severe Adverse Events
Kidney impairment, Liver damage, Severe allergic reaction (Angioedema), Neutropenia
Common Side Effects
Dizziness, Dry cough, Fatigue
Uncommon Side Effects
Muscle cramps, Low blood pressure, Electrolyte imbalance
Drug Interactions
Lithium, Potassium supplements, NSAIDs, Aliskiren
Pregnancy Safety Warnings
Do not use in pregnancy (risk of foetal harm)
Age Restrictions
Adults only
Storage Guidelines
Keep in original packaging at room temperature
Related Products
Lisinopril/HCTZ, Ramipril, Co-diovan

Vaseretic FAQ

Can Vaseretic be taken with other blood-pressure medicines?

Yes, Vaseretic is often prescribed alongside other antihypertensives such as beta-blockers or calcium-channel blockers to achieve target blood pressure. However, the combined effect can be additive, so dose adjustments and close monitoring of blood pressure and renal function are recommended.

What should I do if I develop a persistent dry cough while on Vaseretic?

A dry cough is a recognized side effect of the enalapril component. If the cough is bothersome or persistent, contact your prescriber; they may switch you to a different ACE inhibitor or an angiotensin II receptor blocker (ARB) that does not cause cough.

Is Vaseretic safe for people with a history of gout?

Hydrochlorothiazide can raise serum uric acid levels, potentially triggering gout attacks. Patients with a known history of gout should discuss alternative antihypertensive options with their clinician or consider prophylactic urate-lowering therapy.

How does Vaseretic affect potassium levels?

Enalapril can increase potassium retention, while hydrochlorothiazide promotes potassium loss. The combined effect usually balances potassium levels, but regular monitoring is essential, especially in patients on potassium supplements or other potassium-affecting drugs.

Can I travel internationally with Vaseretic?

Yes, Vaseretic can be taken while traveling. Carry the medication in its original packaging with the prescription label, and bring a copy of the prescription or a doctor’s note in case customs or security checks request verification.

Do I need to avoid salty foods while on Vaseretic?

A low-salt diet helps optimize the diuretic effect of hydrochlorothiazide and supports overall blood-pressure control. Reducing excessive sodium intake is advisable but does not require complete elimination.

What are the visual characteristics of Vaseretic tablets?

Vaseretic tablets are typically round, film-coated, and bear a specific imprint code unique to the manufacturer. The appearance may vary by batch; always verify the imprint against the pharmacy label.

Is Vaseretic tested in drug-screening programs for athletes?

Neither enalapril nor hydrochlorothiazide is listed as a prohibited substance by major anti-doping agencies. However, thiazide diuretics are sometimes monitored for potential masking of other substances, so athletes should disclose usage to their governing body.

How does Vaseretic compare with taking enalapril and hydrochlorothiazide separately?

Combining the two agents in a single tablet simplifies dosing, improves adherence, and reduces pill burden. Pharmacologically, the effects are equivalent to taking the separate components at the same doses.

Can Vaseretic cause weight loss?

The diuretic component may lead to a modest reduction in fluid weight, especially early in therapy. This is not a true loss of body fat and should not be considered a weight-loss strategy.

Vaseretic: What Is It?

Vaseretic is a combination medication that contains enalapril and hydrochlorothiazide as its active ingredients. It belongs to the heart and blood-pressure therapeutic class and is supplied as a 10 mg / 25 mg pill. In the United Kingdom Vaseretic is a prescription-only medicine (POM) regulated by the Medicines and Healthcare products Regulatory Agency (MHRA).

How Vaseretic Works in the Body

  • Enalapril is an angiotensin-converting enzyme (ACE) inhibitor. By blocking the conversion of angiotensin I to the vasoconstrictor angiotensin II, it relaxes blood vessels, reduces peripheral resistance, and lowers blood pressure.
  • Hydrochlorothiazide is a thiazide-type diuretic. It promotes the excretion of sodium and water in the kidneys, decreasing blood-volume overload and further contributing to blood-pressure reduction.

Together, these agents provide a dual-action approach: vascular relaxation from enalapril and fluid reduction from hydrochlorothiazide. The combined effect typically begins within a few hours of the first dose, with the full blood-pressure-lowering response evident after several days of consistent use.

Conditions Treated by Vaseretic

Vaseretic is approved by the MHRA for the treatment of hypertension (high blood pressure) when monotherapy with either enalapril or hydrochlorothiazide alone does not achieve target blood-pressure control. It is intended for adult patients who require both an ACE inhibitor and a thiazide diuretic to reach their therapeutic goals.

Off-Label and Investigational Applications

No robust peer-reviewed evidence or UK guideline support exists for off-label uses of Vaseretic. Consequently, this section is omitted.

Who Should (Not) Use Vaseretic?

Ideal Candidates

  • Adults with diagnosed hypertension who need combination therapy to reach target blood pressure.
  • Patients who tolerate both ACE inhibitors and thiazide diuretics.

Absolute Contraindications

  • Known hypersensitivity to enalapril, hydrochlorothiazide, or any tablet component.
  • History of angio-edema related to previous ACE-inhibitor therapy.
  • Severe renal impairment (eGFR < 30 mL/min/1.73 m²) in the absence of specialist supervision.
  • Pregnancy (ACE inhibitors are contraindicated in the second and third trimesters; thiazides are avoided in early pregnancy if alternatives exist).

Relative Contraindications and Precautions

  • Moderate renal impairment (eGFR 30-60 mL/min/1.73 m²) - dose may need adjustment.
  • Hepatic impairment - monitor electrolytes and renal function.
  • Electrolyte disturbances (especially low potassium or sodium levels).
  • Diabetes mellitus - thiazides can increase blood glucose; monitor glycated hemoglobin.
  • Gout - thiazides may raise serum uric acid; consider prophylaxis if necessary.
  • Elderly patients - start at the lowest effective dose and monitor renal function closely.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Cough (dry, persistent) - frequently reported with ACE inhibitors.
  • Dizziness or light-headedness - usually due to lowered blood pressure, especially after the first doses.
  • Increased urination - a typical effect of the diuretic component.
  • Mild electrolyte changes (e.g., low potassium) - monitor labs periodically.

Serious Adverse Events

  • Angio-edema - swelling of the face, lips, tongue, or throat requiring immediate medical attention.
  • Severe hypotension - especially after the first dose or when standing up quickly.
  • Significant electrolyte imbalance (hyper-kalaemia, hyponatraemia) - may necessitate treatment interruption.
  • Acute renal failure - indicated by abrupt rise in serum creatinine; stop the drug and seek urgent care.

Drug Interactions

  • Potassium-sparing diuretics, supplements or salt substitutes - may exacerbate hyper-kalaemia.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) - can blunt antihypertensive effect and impair renal function.
  • Lithium - thiazides can increase lithium levels; close monitoring required.
  • Other antihypertensives (beta-blockers, calcium channel blockers) - additive blood-pressure-lowering effect; dosage adjustments may be needed.
  • Antidiabetic agents - thiazides may raise blood glucose; consider dose changes.

Food and Lifestyle Interactions

  • Alcohol - may enhance hypotensive effect; moderate consumption is advised.
  • High-salt diets - counteract the diuretic effect; a low-salt diet supports therapeutic goals.
  • Driving or operating machinery - avoid if you feel dizzy or light-headed until you know how Vaseretic affects you.

If specific interaction data for Vaseretic are limited, patients should disclose all medicines, supplements, and herbal products to their prescriber.

How to Take Vaseretic

  • Standard dosing: One tablet (10 mg enalapril / 25 mg hydrochlorothiazide) taken once daily, preferably in the morning.
  • Dose adjustments: May be reduced to a lower strength (e.g., 5 mg/12.5 mg) if blood pressure falls too low or if renal function declines.
  • Special populations:
  • Renal impairment - start with a reduced dose and monitor creatinine and electrolytes.
  • Elderly - consider lower initial dose; titrate slowly.
  • Administration: Swallow the tablet whole with a full glass of water. It can be taken with or without food.
  • Missed dose: Take the missed dose as soon as you remember, unless it is near the time of the next scheduled dose. Do not double the dose.
  • Overdose: Symptoms may include severe hypotension, fainting, or electrolyte disturbances. Seek emergency care; supportive measures such as intravenous fluids and blood-pressure monitoring are standard.
  • Discontinuation: Do not stop abruptly without medical advice; a gradual taper may be recommended to avoid rebound hypertension.

Monitoring and Follow-Up

  • Blood pressure: Check weekly until stable, then at routine clinical intervals.
  • Renal function: Serum creatinine and eGFR measured within 1-2 weeks of initiation, then periodically.
  • Electrolytes: Sodium, potassium, and chloride levels should be assessed after the first month and annually thereafter.
  • Blood glucose: For diabetic patients, monitor HbA1c every 3-6 months.
  • Clinical review: Report persistent cough, swelling, or signs of electrolyte imbalance promptly to a healthcare professional.

Storage and Handling

  • Store Vaseretic tablets at room temperature (15-30 °C), away from moisture and direct sunlight.
  • Keep the container tightly closed and out of reach of children.
  • Do not use after the expiry date printed on the pack.
  • Dispose of unused tablets via a pharmacy take-back scheme or follow local NHS guidelines for medication waste.

Medication-Specific Glossary

ACE inhibitor
A drug class that blocks the enzyme converting angiotensin I to angiotensin II, leading to vasodilation and lowered blood pressure.
Thiazide diuretic
A type of diuretic that increases the excretion of sodium and water by acting on the distal convoluted tubule of the kidney, helping to reduce blood volume.
Angio-edema
A rapid swelling of the deeper layers of the skin or mucous membranes, potentially life-threatening when it involves the airway.
eGFR
Estimated glomerular filtration rate, a measure of kidney function used to adjust dosing of renally excreted medicines.
Therapeutic window
The range of drug concentrations in the blood that provides efficacy without unacceptable toxicity.

Medical Disclaimer

This article provides educational information about Vaseretic and is not a substitute for professional medical advice. Treatment decisions, including the use of any medication for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Vaseretic is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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