Buy Uroxatral
Uroxatral

1.39
Uroxatral (alfuzosin) is an alpha-blocker used to treat symptoms of benign prostatic hyperplasia in men. It works by relaxing the muscles in the prostate and bladder neck, making it easier for patients to urinate. This medication helps manage urinary flow and reduces the urge to urinate frequently.


Ingredient
Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Alfuzosin
Reference Brand
Xatral
Manufacturer
Sanofi-Aventis
Product Form
Prolonged-release tablet
Regulatory Classification
Rx
Primary Category
Prostate Treatment
Product Category
Genito-urinary system, Drugs used in benign prostatic hypertrophy, Alpha-adrenoreceptor antagonists
Pharmacological Class
Alpha-1 blocker
Manufacturer Description
A treatment for men with symptoms of an enlarged prostate, designed to improve urination.
Mechanism of Action
Alfuzosin relaxes the muscles in the prostate and the neck of the bladder. This relaxation reduces pressure on the urethra, making it easier for men with an enlarged prostate to urinate and improving overall urine flow.
Route of Administration
Oral
Onset Time
Few days for initial improvement
Duration
24 hours
Contraindications
Moderate to severe liver impairment, Concurrent use of potent CYP3A4 inhibitors, History of orthostatic hypotension
Severe Adverse Events
Prolonged or painful erection, Fainting, Irregular heartbeat, Chest pain
Common Side Effects
Dizziness, Headache, Tiredness
Uncommon Side Effects
Nausea, Abdominal pain, Nasal congestion
Drug Interactions
Ketoconazole, Ritonavir, Atenolol, Sildenafil
Pregnancy Safety Warnings
Not indicated for use in women.
Age Restrictions
Not for use in children
Storage Guidelines
Store in a cool, dry place.
Related Products
Tamsulosin, Doxazosin, Terazosin

Uroxatral FAQ

Can I travel internationally with Uroxatral tablets?

Yes, Uroxatral can be taken abroad, but keep the medication in its original packaging with the prescription label visible. Some countries may require a copy of the prescription at customs, so carrying a doctor's note is advisable.

Does Uroxatral affect urine drug testing for employment or sports?

Alfuzosin is not a prohibited substance in standard drug-screening panels for employment or athletics, and it does not cause a positive result for common illicit-drug tests.

What does a Uroxatral tablet look like?

The 10 mg alfuzosin tablet is typically white, round, and bears the imprint “ALF 10”. Appearance can vary slightly between manufacturers, so verify the imprint against the pharmacy label.

Are there any dietary restrictions while taking Uroxatral?

No specific foods need to be avoided. However, taking the tablet with the same meal each day helps maintain consistent absorption.

How does Uroxatral compare with tamsulosin for BPH?

Both are selective α-1 blockers, but alfuzosin (Uroxatral) has a higher affinity for the α-1A subtype and is taken once daily without the need for a timed dosing window. Tamsulosin is sometimes taken 30 minutes before the first meal of the day. Choice of agent depends on individual response and tolerance.

Can I take Uroxatral if I have a pacemaker?

Generally, alfuzosin does not interfere with cardiac pacemaker function. Nevertheless, patients with significant cardiac conditions should discuss any concerns with their cardiologist before initiating therapy.

What should I do if I experience persistent dizziness?

Stand up slowly from sitting or lying positions, stay hydrated, and avoid driving until the symptom resolves. If dizziness continues or is severe, contact your prescriber for evaluation.

Is a generic version of alfuzosin available in the UK?

Yes, several generic alfuzosin tablets are marketed at the same 10 mg strength. They contain the same active ingredient and are considered therapeutically equivalent to Uroxatral.

How long can I stay on Uroxatral therapy?

Uroxatral can be used long-term as long as it continues to provide symptom relief and is well tolerated. Regular review by a healthcare professional is recommended to assess ongoing need.

What is the history behind the development of alfuzosin?

Alfuzosin was first synthesized in the 1990s as part of a series of selective α-1 blockers aimed at treating BPH with fewer cardiovascular side effects. It received MHRA approval in the early 2000s and has been marketed under the brand name Uroxatral since then.

What is Uroxatral?

Uroxatral is a prescription-only medication marketed in the United Kingdom for the treatment of lower urinary tract symptoms caused by an enlarged prostate, a condition medically known as benign prostatic hyperplasia (BPH).

  • Active ingredient: Alfuzosin
  • Therapeutic class: Men’s-health α-blocker (selective α-1A adrenergic receptor antagonist)
  • Formulation: Oral pill (tablet)
  • Strengths available: 10 mg per tablet
  • Regulatory status: Licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) and requires a prescription from a qualified prescriber.

Uroxatral belongs to a group of medications that relax smooth muscle in the prostate and bladder neck, thereby improving urine flow and reducing urinary urgency and frequency.

How Uroxatral Works in the Body

Alfuzosin selectively blocks α-1A adrenergic receptors that are densely located in the smooth muscle of the prostate gland and the internal urethral sphincter. By inhibiting these receptors:

  • Smooth-muscle relaxation occurs in the prostate and bladder neck.
  • Resistance to urinary outflow is lowered, which allows the bladder to empty more completely.
  • Onset of symptom relief is usually observed within a few days, with maximal effect reached after several weeks of continuous therapy.

Because alfuzosin is highly selective for the α-1A subtype, it tends to cause fewer cardiovascular side effects (such as a drop in blood pressure) compared with non-selective α-blockers.

Conditions Treated by Uroxatral

Uroxatral is approved by the MHRA for the following indication:

  • Benign prostatic hyperplasia (BPH) - relief of moderate to severe lower urinary tract symptoms (LUTS) such as weak stream, nocturia, urgency, and incomplete bladder emptying in adult men.

The medication is intended for use in men who have a confirmed diagnosis of BPH and who experience bothersome symptoms that affect daily life.

Patient Suitability and Contraindications

Who Should Not Use Uroxatral?

  • Known hypersensitivity to alfuzosin or any of the tablet’s excipients.
  • Severe hepatic impairment (Child-Pugh class C) - the drug’s metabolism is reduced, raising plasma concentrations.
  • Concurrent use of potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin) - may increase alfuzosin levels and risk of hypotension.

Relative Contraindications & Cautions

  • Mild to moderate hepatic dysfunction - dose adjustment is not recommended; careful monitoring is advised.
  • Renal impairment - no dose change is required for mild to moderate disease, but caution is advised in severe renal failure.
  • Cardiovascular conditions (e.g., orthostatic hypotension, uncontrolled hypertension) - monitor blood pressure after initiating therapy.
  • Elderly patients - may be more sensitive to blood-pressure-lowering effects; start at the recommended dose and observe tolerance.

Special Populations

  • Pregnancy & lactation: Not indicated; BPH does not occur in women, and safety data are lacking.
  • Pediatric use: Not approved.
  • Geriatric patients: No dose reduction is required solely because of age, but increased vigilance for dizziness or falls is prudent.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Dizziness or light-headedness (especially after the first dose)
  • Headache
  • Fatigue or tiredness
  • Nasal congestion or runny nose
  • Upper respiratory tract infection-like symptoms

These effects are generally mild, transient, and often resolve without medical intervention.

Serious Adverse Events

  • Severe hypotension (marked drop in blood pressure) - may cause fainting; seek urgent care if symptoms arise.
  • Priapism (prolonged erection) - a rare urological emergency; immediate medical attention required.
  • Syncope (sudden loss of consciousness) - may indicate excessive blood-pressure lowering.

If any of these serious reactions occur, discontinue the medication and contact a healthcare professional promptly.

Drug Interactions

  • Major interactions: Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, ritonavir) can raise alfuzosin concentrations, increasing the risk of hypotension.
  • Moderate interactions: Other α-blockers (e.g., tamsulosin, terazosin) may have additive blood-pressure-lowering effects; concurrent use should be avoided unless specifically directed.
  • Other medications: Antihypertensives (e.g., ACE inhibitors, diuretics) may enhance the blood-pressure-lowering effect; monitor blood pressure regularly.

Patients should provide a complete medication list-including over-the-counter drugs, herbal supplements, and vitamins-to their prescriber before starting Uroxatral.

Food and Lifestyle Interactions

  • Food: Alfuzosin can be taken with or without food, but consistency is recommended; taking the tablet at the same time each day, preferably after the same meal, helps maintain steady blood levels.
  • Alcohol: Moderate consumption is unlikely to cause a problem, but excessive alcohol may increase dizziness.
  • Driving or operating machinery: Caution is advised during the first few days of therapy, as dizziness may impair coordination.
  • Sun exposure: No specific photosensitivity has been reported for alfuzosin.

How to Take Uroxatral

  • Standard dosing: One 10 mg tablet taken orally once daily.
  • Timing: Preferably after the same meal each day (e.g., breakfast). Consistency reduces fluctuations in drug absorption.
  • Administration: Swallow the tablet whole with a glass of water; do not split, crush, or chew.
  • Missed dose: If a dose is missed, take it as soon as remembered provided it is at least 12 hours before the next scheduled dose. Do not double the dose to compensate.
  • Overdose: Symptoms may include profound dizziness, fainting, or severe low blood pressure. Seek emergency medical care; supportive measures such as intravenous fluids and vasopressors may be required.
  • Discontinuation: No tapering is required for alfuzosin. If therapy is stopped, urinary symptoms may return gradually; discuss alternative management with a prescriber.

Dosing adjustments for renal or hepatic impairment are not required for the 10 mg tablet, but clinicians may choose a more cautious approach in severe organ dysfunction.

Monitoring and Follow-Up

  • Blood pressure: Check baseline and periodic blood pressure, especially after the first week of treatment.
  • Symptom assessment: Use a validated questionnaire (e.g., International Prostate Symptom Score) to gauge improvement.
  • Laboratory tests: Routine liver function tests are not mandatory but may be considered in patients with known liver disease.
  • When to contact a provider: Persistent dizziness, fainting, severe hypotension, or any new urinary symptoms should be reported promptly.

Regular follow-up appointments allow the prescriber to evaluate therapeutic benefit, adjust dosing if necessary, and monitor for adverse effects.

Storage and Handling

  • Temperature: Store at ≤ 30 °C in a dry place away from direct sunlight.
  • Moisture: Keep the bottle tightly closed to protect tablets from humidity.
  • Child safety: Ensure the container is out of reach of children; use a child-resistant cap if supplied.
  • Expiration: Do not use tablets beyond the printed expiry date; discard any damaged or discolored tablets.
  • Disposal: Follow local pharmacy guidelines for the safe disposal of unused medication.

Medication-Specific Glossary

Alpha-1A adrenergic receptor
A subtype of the α-1 adrenergic receptor predominantly located in prostatic smooth muscle; blockade leads to muscle relaxation and improved urine flow.
Benign prostatic hyperplasia (BPH)
A non-cancerous enlargement of the prostate gland that commonly causes lower urinary tract symptoms in men over 50 years of age.
Urinary flow rate
The speed at which urine is expelled from the bladder; a key objective measure that improves when prostate smooth muscle is relaxed.

Medical Disclaimer

This article provides educational information about Uroxatral and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Uroxatral is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
Categories
Waar kunt u Geestelijke Gezondheid veilig aanschaffen - Seroquel tabletten Order medications for Men's Prescription Online: - Buy Finasteride Hong Kong