Buy Ultravate
Ultravate

21.25
Ultravate (halobetasol) is a high-potency topical corticosteroid formulated to alleviate the symptoms of various inflammatory skin disorders, such as psoriasis or severe dermatitis. It works by reducing swelling, itching, and redness. This treatment provides targeted relief for localized skin irritation and supports the restoration of healthy skin barrier function.


Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Halobetasol Propionate
Manufacturer
Sun Pharmaceutical
Product Form
Cream, Ointment
Regulatory Classification
Rx
Primary Category
Skin Care, Steroid Treatment
Product Category
Corticosteroids, Potent Steroids
Pharmacological Class
Topical Glucocorticoid
Clinical Indications
Manufacturer Description
A very potent topical steroid used for short-term treatment of inflammatory skin conditions like psoriasis.
Mechanism of Action
Halobetasol is a high-potency corticosteroid that reduces the chemicals in the body that cause inflammation. It suppresses the immune response in the skin to reduce redness, swelling, and itching.
Route of Administration
Topical
Onset Time
1-3 days
Duration
Up to 2 weeks
Contraindications
Rosacea, Acne, Skin infections (viral, bacterial, or fungal)
Severe Adverse Events
Adrenal suppression, Cushing's syndrome, Vision problems
Common Side Effects
Stinging, Burning, Dry skin
Uncommon Side Effects
Skin thinning, Stretch marks, Itching
Drug Interactions
Other topical steroids
Pregnancy Safety Warnings
Use only if clearly needed and prescribed.
Age Restrictions
Not recommended for children <12
Storage Guidelines
Store at room temperature; do not freeze.
Related Products
Dermovate, Clobetasol

Ultravate FAQ

Can Ultravate be used on the face?

Ultravate is a high-potency corticosteroid and is generally avoided on the face because the skin there is thin and more prone to atrophy and steroid-induced rosacea. A dermatologist may prescribe a lower-potency steroid for facial lesions.

How long can I safely use a 30 g tube of Ultravate?

Typical short-term therapy lasts up to 2 weeks. Using the entire tube on a limited area within this period is acceptable, but extending treatment beyond the recommended duration increases the risk of side effects and should be discussed with a clinician.

Does Ultravate require a prescription in the UK?

Yes. Ultravate is classified as a prescription-only medicine (POM) by the MHRA and must be dispensed with a valid NHS or private prescription.

What should I do if I notice skin thinning under the tube?

Discontinue Ultravate immediately and contact your healthcare provider. Skin atrophy is a sign of excessive steroid exposure and may require an alternative treatment plan.

Can I apply Ultravate under a occlusive dressing?

Occlusion markedly increases drug absorption and the risk of systemic effects. It should only be done under specialist instruction, typically for a very short period and on limited skin areas.

Is it safe to use Ultravate while breastfeeding?

Topical halobetasol can be absorbed systemically in small amounts. While occasional use on a small area is unlikely to affect a breastfed infant, routine or extensive use should be discussed with a health professional to weigh benefits against potential risks.

Does Ultravate interact with oral steroids I’m taking for asthma?

Concurrent use of multiple corticosteroids can increase the overall steroid load, potentially suppressing the HPA axis. Your prescriber may adjust dosages or monitor cortisol levels to prevent adverse effects.

What should I avoid while using Ultravate?

Avoid using other topical irritants (e.g., retinoids, harsh soaps) on the same area, and refrain from applying it to broken skin, open wounds, or infected lesions unless directed by a clinician.

Can Ultravate be used on children under 12 years old?

Use in children under 12 is generally reserved for specialist care. The higher potency raises the risk of systemic absorption and growth suppression, so a pediatric dermatologist should evaluate the need and dosage.

How does Ultravate differ from other topical steroids like betamethasone?

Halobetasol propionate is classified as a super-high-potency (class I) steroid, whereas betamethasone is typically medium to high potency (class II-III). This means Ultravate produces a stronger anti-inflammatory effect but also carries a greater risk of side effects if misused.

What is Ultravate?

Ultravate contains halobetasol propionate as its active component. It belongs to the class of high-potency topical corticosteroids and is supplied in a 30 g tube. In the United Kingdom, Ultravate is a prescription-only medicine (POM) regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). It is intended for short-term treatment of inflammatory skin conditions where a strong anti-inflammatory effect is required.

How Ultravate Works in the Body

Halobetasol propionate is a synthetic glucocorticoid. When applied to the skin it:

  • Binds to intracellular glucocorticoid receptors, altering gene transcription.
  • Reduces production of inflammatory mediators such as prostaglandins and leukotrienes.
  • Suppresses the activity of immune cells (e.g., T-lymphocytes, macrophages) in the skin.
  • Causes vasoconstriction, leading to decreased swelling and erythema.

These actions together diminish redness, itching, and thickness associated with conditions like psoriasis and severe eczema. Because the drug is applied topically, systemic absorption is generally low, but it can increase with extensive use or use over large surface areas.

Conditions Treated by Ultravate

Ultravate is approved in the UK for the short-term (usually up to 2 weeks) management of:

  • Plaque psoriasis
  • Chronic plaque eczema (atopic dermatitis) that has not responded to milder corticosteroids
  • Lichen planus
  • Other inflammatory dermatoses where a high-potency corticosteroid is indicated

Treatment is targeted to the affected areas and is not intended for large-area or whole-body use except under specialist supervision.

Patient Suitability and Contraindications

Who Should Use Ultravate?

  • Adults with moderate-to-severe plaque psoriasis or eczema requiring a high-potency steroid.
  • Patients who have not achieved adequate control with lower-potency topical steroids.

Absolute Contraindications

  • Known hypersensitivity to halobetasol propionate or any excipients in the tube.
  • Skin infections (bacterial, fungal, viral) at the treatment site unless antimicrobial therapy is also being used.
  • Untreated rosacea or perioral dermatitis.

Relative Contraindications

  • Children under 12 years of age (use only under specialist advice).
  • Pregnant or breastfeeding women - corticosteroids can be absorbed systemically; risk-benefit assessment required.
  • Patients with severe liver disease, uncontrolled diabetes, or hypertension where systemic corticosteroid exposure could exacerbate the condition.

Special Populations

  • Elderly: Skin is thinner; use the smallest effective amount and limit duration.
  • Patients with compromised skin barrier (e.g., atopic skin): Monitor closely for irritation or secondary infection.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Mild skin irritation or burning sensation at the application site
  • Transient itching or dryness
  • Minor thinning of the skin (atrophy) with prolonged use

Serious Adverse Events

  • Significant skin atrophy or striae with excessive or prolonged application
  • Hypothalamic-pituitary-adrenal (HPA) axis suppression, especially when used over large areas or under occlusion
  • Secondary skin infections (impetigo, candidiasis)

If any of these occur, discontinue use and seek medical advice promptly.

Drug Interactions

Topical halobetasol has limited systemic interaction potential. However:

  • Concurrent use of other potent corticosteroids (systemic or topical) may increase the risk of HPA-axis suppression.
  • Certain antifungal or antibacterial creams containing tretinoin or other irritants may exacerbate local skin irritation.

Food and Lifestyle Interactions

  • No known food interactions. Apply to clean, dry skin and allow the medication to dry before dressing.
  • Alcohol consumption does not affect topical absorption but may influence systemic corticosteroid effects if other steroids are used.
  • Driving or operating machinery is not impaired by Ultravate.

General Advice: Inform your pharmacist of all medicines, supplements, and herbal products you use before starting Ultravate.

How to Take Ultravate

  • Standard dosing: Apply a thin layer (approximately the size of a pea) to the affected area once daily, preferably in the evening. Do not exceed the amount that can be spread thinly over the skin.
  • Maximum amount: A 30 g tube typically supplies treatment for several weeks when used as directed; avoid using the entire tube on a single area.
  • Special populations: For children or patients with extensive disease, a dermatologist may prescribe reduced frequency (e.g., every other day) or lower-potency alternatives.
  • Administration: Squeeze an appropriate amount from the tube, spread gently with fingertip, and allow it to absorb fully before covering with clothing.
  • Missed dose: Apply the missed dose at the next scheduled time; do not double the dose.
  • Overdose: Signs of systemic corticosteroid excess include facial flushing, rapid weight gain, or elevated blood pressure. Seek urgent medical care if you suspect overdose.
  • Discontinuation: Do not stop abruptly after long-term use. Gradual tapering under medical supervision reduces the risk of rebound inflammation and HPA-axis suppression.

Monitoring and Follow-Up

  • Clinical review: Re-evaluate skin response after 1-2 weeks of therapy. If no improvement, the healthcare provider may adjust treatment.
  • Laboratory tests: Routine blood tests are not required for short courses. In cases of extensive use or suspected HPA suppression, serum cortisol may be measured.
  • When to seek help: New or worsening skin infection, severe skin thinning, or systemic symptoms such as unexplained fatigue or dizziness.

Storage and Handling

  • Keep the tube tightly capped and store at room temperature (15-25 °C) away from direct sunlight and moisture.
  • Do not freeze. If the product appears discolored or the consistency changes, discard it.
  • Keep out of reach of children. Use a child-proof container if the original tube is transferred to another holder.

Medication-Specific Glossary

Glucocorticoid receptor
A cellular protein that, when activated by corticosteroids, modulates gene expression to reduce inflammation.
Hypothalamic-pituitary-adrenal (HPA) axis
The hormonal system that regulates cortisol production; prolonged potent steroid use can suppress its activity.
Skin atrophy
Thinning of the skin layers that may occur with excessive or prolonged high-potency steroid application.

Medical Disclaimer

This article provides educational information about Ultravate and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Ultravate is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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