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Tricor

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Tricor (Fenofibrate) is a fibric acid derivative used to treat high blood cholesterol and triglyceride levels. It works by increasing the natural breakdown of fats in the blood, helping to prevent pancreatitis and cardiovascular risks. This medication supports adults in maintaining healthy lipid profiles alongside dietary changes.


Ingredient
Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Fenofibrate
Reference Brand
Lipantil
Manufacturer
Abbott
Product Form
Tablets, Capsules
Regulatory Classification
Rx
Primary Category
Cholesterol Management
Product Category
Cardiovascular system, Lipid modifying agents, Fibrates
Pharmacological Class
Fibrate
Manufacturer Description
Used alongside diet to reduce high levels of harmful fats and cholesterol in the blood.
Mechanism of Action
Fenofibrate activates a specific receptor (PPAR-alpha) which increases the breakdown of fats in the blood and reduces the production of 'bad' cholesterol and triglycerides by the liver.
Route of Administration
Oral
Onset Time
Requires several weeks for full effect
Duration
Ongoing as long as taken
Contraindications
Severe liver disease, Severe kidney disease, Gallbladder disease, Chronic pancreatitis
Severe Adverse Events
Muscle breakdown (rhabdomyolysis), Hepatitis, Pancreatitis, Gallstones
Common Side Effects
Digestive upset, Nausea, Flatulence
Uncommon Side Effects
Headache, Skin rash, Muscle pain
Drug Interactions
Statins, Warfarin, Ciclosporin, Colchicine
Pregnancy Safety Warnings
Not recommended during pregnancy.
Age Restrictions
Adults
Storage Guidelines
Store in the original package at room temperature.
Related Products
Bezafibrate, Atorvastatin, Gemfibrozil

Tricor FAQ

Can I take Tricor if I am already on a statin?

Yes, Tricor is often prescribed alongside a statin to address persistent high triglycerides. However, the combination increases the risk of muscle-related side effects, so the prescribing clinician should select a statin with a lower interaction potential and monitor muscle enzymes regularly.

What should I do if I develop a rash while using Tricor?

A mild rash may resolve on its own, but any skin reaction that is widespread, itchy, or accompanied by fever should be reported to a healthcare professional promptly. Discontinuation may be necessary if the rash is judged to be drug-related.

Is Tricor safe for people with mild kidney disease?

For patients with a creatinine clearance of 30-50 mL/min, Tricor can be used at the lower 160 mg dose with careful monitoring of renal function. Doses above 160 mg are generally avoided in this group.

How long does it take to see an improvement in triglyceride levels?

Most patients notice a reduction in triglycerides within 2-4 weeks, with the greatest effect typically observed after 8-12 weeks of continuous therapy.

Can I travel internationally with Tricor tablets?

Yes, but keep the medication in its original labeled container, carry a copy of the prescription, and be aware of any country-specific import restrictions on prescription drugs. The UK’s MHRA permits personal use quantities for travel.

Does Tricor interact with over-the-counter supplements such as fish oil?

Fish oil also lowers triglycerides and may have additive effects, but it generally does not cause harmful interactions. Nevertheless, inform your prescriber about any supplements you are taking to ensure coordinated care.

Will taking Tricor affect my blood test for cholesterol?

Tricor is designed to lower triglycerides and raise HDL-C; it may modestly lower LDL-C. Your lipid panel will reflect these changes, which your clinician will interpret in the context of overall cardiovascular risk.

Is it necessary to fast before having blood drawn while on Tricor?

Fasting is recommended for accurate triglyceride measurement, regardless of medication. Continue taking Tricor as prescribed; do not skip doses before the test.

Can Tricor be crushed or split to adjust the dose?

Fenofibrate tablets are formulated for whole-tablet administration. Crushing or splitting may alter absorption and is not advised unless a specialist formulation is provided.

What is the cost difference between the 160 mg and 200 mg tablets?

Pricing varies by pharmacy and NHS prescription status. The 200 mg tablet is typically more expensive per tablet but may reduce the total number of tablets needed for a given dose. For exact costs, consult your local pharmacy or NHS prescription service.

What is Tricor?

Tricor is a prescription medication that contains fenofibrate as its active component. Fenofibrate belongs to the cholesterol-lowering class of drugs known as fibrates. The product is supplied as a solid oral pill and is available in the United Kingdom in two strengths: 160 mg and 200 mg. Tricor is marketed under a licence issued by the Medicines and Healthcare products Regulatory Agency (MHRA) and is prescribed for the management of certain lipid disorders.

How Tricor Works in the Body

Fenofibrate activates peroxisome proliferator-activated receptor-α (PPAR-α), a nuclear transcription factor that regulates genes involved in lipid metabolism. By stimulating PPAR-α, Tricor:

  • Increases the oxidation of fatty acids in the liver and muscle, reducing circulating triglyceride levels.
  • Enhances the synthesis of high-density lipoprotein (HDL) cholesterol, which helps remove excess cholesterol from peripheral tissues.
  • Lowers very-low-density lipoprotein (VLDL) production, further contributing to triglyceride reduction.

The therapeutic effect typically begins within 1-2 weeks, with maximal lipid changes observed after 4-8 weeks of continuous therapy. Fenofibrate is well absorbed after oral administration; food increases its bioavailability modestly, but the drug can be taken with or without meals. The compound is extensively metabolised in the liver and excreted primarily via the bile.

Conditions Treated by Tricor

Tricor is approved by the MHRA for the treatment of adults with:

  • Severe hypertriglyceridaemia (fasting triglycerides ≥ 2.3 mmol/L) when lifestyle measures alone are insufficient.
  • Mixed dyslipidaemia characterised by elevated triglycerides together with low HDL-cholesterol, especially when statin therapy does not achieve target lipid levels.

The medication is intended for patients who are already following a low-fat diet and who may also be receiving statins, provided that combined therapy is deemed appropriate by a prescriber. Tricor is not indicated for primary prevention of cardiovascular disease in patients with normal lipid profiles.

Who Should Not Use Tricor?

Absolute Contraindications

  • Known hypersensitivity to fenofibrate, any other fibrate, or any excipients in the tablet.
  • Severe liver disease (elevated transaminases > 3 × upper limit of normal) or active hepatic inflammation.
  • End-stage renal disease (creatinine clearance < 30 mL/min).
  • Pregnancy (category X) - fenofibrate is contraindicated because of potential fetal harm.
  • Breast-feeding - the drug passes into milk and may affect the infant.

Relative Contraindications

  • Moderate renal impairment (creatinine clearance 30-50 mL/min) - dose adjustment may be required.
  • History of gallstones - fenofibrate can increase biliary cholesterol saturation.
  • Concomitant use of statins at high doses - increased risk of myopathy.
  • Thyroid disorders - lipid response may be altered; monitor thyroid function.

Special Populations

  • Pregnancy & lactation: Tricor must be avoided.
  • Elderly: Reduced renal function is common; start at the lowest dose and monitor renal parameters.
  • Patients with hepatic impairment: Use only if benefits outweigh risks and under close supervision.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Gastro-intestinal upset - nausea, abdominal discomfort, or diarrhoea (usually mild and transient).
  • Muscle pain - occasional myalgia, particularly when combined with statins.
  • Elevated liver enzymes - mild, reversible increases in ALT/AST.
  • Rash or pruritus - skin reactions that resolve after discontinuation.

Serious Adverse Events

  • Rhabdomyolysis - rare but potentially life-threatening muscle breakdown, more likely with high-dose statin co-therapy. Immediate medical attention is required for unexplained muscle weakness, dark urine, or severe pain.
  • Severe hepatotoxicity - marked elevation of liver enzymes, jaundice, or hepatic failure. Stop the medication and seek urgent care.
  • Renal dysfunction - acute decline in renal function has been reported, especially in patients with pre-existing kidney disease.

Drug Interactions

  • Statins (especially simvastatin, lovastatin): Concomitant use increases the risk of myopathy and rhabdomyolysis. Dose-reduce the statin or choose a statin with a lower interaction potential (e.g., pravastatin).
  • Anticoagulants (warfarin): Fenofibrate may potentiate anticoagulant effects; monitor INR more frequently after initiation.
  • Cyclosporine: Can raise fenofibrate plasma concentrations, increasing toxicity risk.
  • Bile-acid sequestrants (e.g., cholestyramine): May reduce fenofibrate absorption; separate administration times by at least 1 hour.

If a patient takes other medications, they should discuss the full list with their prescriber, as additional interactions may exist.

Food and Lifestyle Interactions

  • Alcohol: Excessive intake can raise triglyceride levels and increase the risk of liver injury; moderation is advised.
  • High-fat meals: May modestly increase fenofibrate absorption but do not alter the overall therapeutic effect; patients may take the pill with or without food.
  • Driving or operating machinery: No direct impairment, but severe muscle pain or dizziness warrants caution.
  • Sun exposure: No specific photosensitivity reported, but patients with rash should protect affected skin.

How to Take Tricor

  • Standard dosing:

  • Adults typically start with one 160 mg tablet taken once daily.

  • If lipid goals are not achieved, the dose may be increased to 200 mg once daily, provided renal function is adequate.

  • Administration:

  • Swallow the tablet whole with a glass of water.

  • The pill can be taken with or without meals; consistent timing each day helps maintain steady drug levels.

  • Renal or hepatic impairment:

  • For creatinine clearance 30-50 mL/min, consider starting at 160 mg and reassessing after 4 weeks.

  • In moderate hepatic disease, avoid initiating therapy; if already on Tricor, discontinue and monitor liver tests.

  • Missed dose:

  • Take the missed tablet as soon as remembered, unless it is near the time of the next scheduled dose. Do not double the dose.

  • Overdose:

  • Symptoms may include nausea, vomiting, abdominal pain, and dizziness. Seek emergency medical care; supportive care and activated charcoal are standard measures.

  • Discontinuation:

  • Tricor does not require tapering. Stop abruptly under medical advice, but continue regular lipid monitoring to assess the need for alternative therapy.

Monitoring and Follow-Up

  • Baseline labs: Lipid profile (triglycerides, HDL-C, LDL-C), liver function tests (ALT, AST, bilirubin), and renal function (serum creatinine, eGFR).
  • Follow-up labs: Repeat lipid panel after 4-8 weeks to gauge response; then every 3-6 months if stable.
  • Liver and renal monitoring: Check ALT/AST and serum creatinine at 6-week intervals after initiation, then periodically, especially if the dose is increased.
  • Clinical assessment: Evaluate for signs of muscle pain, rash, or hepatic dysfunction at each visit. Promptly report any unexplained symptoms.

Storage and Handling

  • Store Tricor tablets at room temperature (15-25 °C) away from direct sunlight, moisture, and heat.
  • Keep the container tightly closed and out of reach of children.
  • Do not use tablets after the expiry date printed on the pack.
  • For disposal, follow local pharmacy take-back schemes or the MHRA guidelines for medicine waste.

Medication-Specific Glossary

Fenofibrate
A lipid-lowering agent that activates PPAR-α, reducing triglycerides and raising HDL-C.
PPAR-α (Peroxisome Proliferator-Activated Receptor-Alpha)
A nuclear receptor that regulates genes controlling fatty-acid oxidation and lipoprotein metabolism.
Triglycerides
The main form of fat in the bloodstream; elevated levels increase the risk of pancreatitis and cardiovascular disease.
HDL-C (High-Density Lipoprotein Cholesterol)
Often called “good cholesterol”; it transports cholesterol from tissues back to the liver for excretion.
Rhabdomyolysis
A severe breakdown of skeletal muscle that releases myoglobin into the bloodstream, potentially causing kidney injury.

Medical Disclaimer

This article provides educational information about Tricor and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Tricor is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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