Buy Tofisopam
Tofisopam

1.78
Tofisopam is a 2,3-benzodiazepine derivative indicated for the treatment of psychological and somatic symptoms of anxiety. It works by modulating the central nervous system to reduce tension and emotional distress. It is designed for adults who require anxiolytic support while maintaining cognitive alertness and motor coordination.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Tofisopam
Reference Brand
Grandaxin
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Anxiety Relief
Product Category
Psycholeptics, Anxiolytics, Benzodiazepine derivatives
Pharmacological Class
2,3-Benzodiazepine
Manufacturer Description
Used to treat anxiety and emotional tension while maintaining alertness and physical coordination.
Mechanism of Action
A unique benzodiazepine that acts as an anxiolytic but does not have sedative, muscle relaxant, or anticonvulsant properties, helping to reduce anxiety without causing drowsiness.
Route of Administration
Oral
Onset Time
1-2 hours
Duration
6-8 hours
Contraindications
Severe respiratory failure, Sleep apnoea, Coma, First trimester of pregnancy
Severe Adverse Events
Confusion, Seizures, Respiratory depression
Common Side Effects
Nausea, Dry mouth, Headache
Uncommon Side Effects
Irritability, Skin rash, Gastrointestinal upset, Sleep disturbances
Drug Interactions
Immunosuppressants, Anticonvulsants, Antifungals, Alcohol
Pregnancy Safety Warnings
Not recommended during pregnancy, especially the first trimester.
Age Restrictions
Not recommended for children.
Storage Guidelines
Store below 25°C in a dry place.
Related Products
Diazepam, Buspirone, Lorazepam

Tofisopam FAQ

Can I travel internationally with a 50 mg tofisopam tablet?

Yes, but you should carry a copy of the prescription and a letter from your prescriber describing the medical necessity. Some countries require documentation for benzodiazepine-type substances at border control.

What does the imprint on a tofisopam pill look like?

In markets where it is sold, the 50 mg tablet often bears a numeric code such as “50 TOF” or a manufacturer’s logo. Verify the imprint against the pharmacy label before use.

Is tofisopam detectable in standard drug-testing panels?

Standard workplace or sports drug screens typically target classical benzodiazepines (e.g., diazepam, lorazepam). Tofisopam may not be included in routine panels, but specialised testing can detect it.

How does tofisopam differ from classic benzodiazepines like diazepam?

Tofisopam provides anxiolysis with minimal sedation, muscle relaxation, or anticonvulsant activity, whereas classic benzodiazepines exhibit all of these effects. This difference stems from its distinct binding profile at the GABA-A receptor.

Can I take tofisopam with antidepressants such as sertraline?

Co-administration is generally permissible, but both drugs influence serotonin pathways and CNS activity. Monitoring for increased anxiety or sedation is advisable.

What should I do if I miss a dose while on a weekend?

Take the missed dose as soon as you remember, unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular schedule-do not double-dose.

Are there any known risks for patients with glaucoma?

There is no specific evidence linking tofisopam to intra-ocular pressure changes. However, patients with narrow-angle glaucoma should discuss any new CNS-active medication with an ophthalmologist.

Why is tofisopam not available on the NHS?

The MHRA has not granted a marketing authorisation for tofisopam in the UK, largely because alternative anxiolytics with established safety profiles are already available.

Is there a generic version of tofisopam?

Yes, the medication is sold as a generic 50 mg tablet without a brand label in countries where it is approved.

Can I crush or split a tofisopam tablet to adjust the dose?

The tablet is formulated for whole-tablet ingestion. Splitting or crushing may alter absorption and should only be done if explicitly advised by a pharmacist.

Tofisopam: Generic Medication Overview

Tofisopam is a benzodiazepine-derived anxiolytic available as a generic medication. It is marketed in some countries under various brand names, but in the United Kingdom it is not currently listed on the NHS formulary. The active ingredient is tofisopam itself. It is supplied as a 50 mg pill for oral use.

How Tofisopam Works in the Body

Tofisopam belongs to the 1,4-benzodiazepine family. Unlike classic benzodiazepines, it produces anxiety relief with minimal sedation, muscle relaxation, or anticonvulsant effects.

  • GABA modulation: The drug enhances the activity of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain, leading to reduced neuronal excitability.
  • Serotonergic influence: Evidence suggests tofisopam may also affect serotonin pathways, contributing to its anxiolytic profile.
  • Onset and duration: Clinical observations indicate an onset of action within 30-60 minutes after oral intake, with therapeutic effects lasting 6-8 hours.

Conditions Treated by Tofisopam

In regions where it is approved, tofisopam is indicated for the short-term treatment of anxiety disorders and adjustment disorder with anxious mood. It may be used when a non-sedating anxiolytic is preferred.

Regulatory note (UK): To date, the Medicines and Healthcare products Regulatory Agency (MHRA) has not granted a marketing authorisation for tofisopam in the United Kingdom. Patients should only use the medication when prescribed by a qualified prescriber outside the UK and imported in accordance with local law.

Patient Suitability and Contraindications

Who Should Use Tofisopam?

  • Adults experiencing moderate anxiety where sedation is undesirable.
  • Individuals without a history of severe hepatic disease.

Absolute Contraindications

  • Known hypersensitivity to tofisopam or any of its excipients.
  • Severe liver impairment (e.g., Child-Pugh C).
  • Pregnancy (first trimester) and lactation - safety data are insufficient.

Relative Contraindications

  • Elderly patients (≥ 65 years) - dose may need reduction.
  • Renal impairment - monitor for accumulation.
  • Concomitant use of strong central nervous system (CNS) depressants.

If you fall into any of these categories, discuss alternative therapies with your healthcare provider.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Drowsiness - reported as a mild, transient effect.
  • Fatigue or lethargy - often improves after the first few days of treatment.
  • Headache - typically resolves without intervention.

Serious Adverse Events

  • Hepatic enzyme elevation - rare; monitor liver function if therapy extends beyond several weeks.
  • Allergic reactions - rash, pruritus, or swelling require immediate medical attention.

Drug Interactions

  • Major: Co-administration with other CNS depressants (e.g., barbiturates, opioid analgesics) can increase sedation and respiratory depression risk.
  • Moderate: Alcohol, antihistamines, and certain antidepressants (e.g., fluoxetine) may enhance anxiolytic effects; dose adjustment or close monitoring is advised.

Food and Lifestyle Interactions

  • No specific food restrictions are known, but avoid alcohol while taking tofisopam due to additive CNS depression.
  • Caution when driving or operating machinery until you know how the medication affects you.

If you are taking other prescription or over-the-counter products, inform your prescriber to evaluate possible interactions.

How to Take Tofisopam

  • Standard dosing: The 50 mg tablet is commonly prescribed once daily, preferably in the morning to minimise daytime drowsiness.
  • Individualisation: Dose selection and timing must be tailored by a qualified healthcare professional based on symptom severity, age, liver function, and concomitant medications.
  • Administration: Swallow the tablet whole with a glass of water; it may be taken with or without food.
  • Missed dose: If you forget a dose, take it as soon as you remember unless it is near the time of the next scheduled dose. Do not double-dose.
  • Overdose: Symptoms may include profound sedation, respiratory depression, and hypotension. Seek emergency medical care; activated charcoal may be considered if presentation is early.
  • Discontinuation: Abrupt cessation after prolonged use can lead to rebound anxiety. A gradual taper, as directed by a prescriber, is recommended.

Monitoring and Follow-Up

  • Liver function tests (LFTs): Baseline and periodic LFTs are advisable for patients on tofisopam for more than 4 weeks.
  • Clinical assessment: Evaluate anxiety scores and adverse effects at each follow-up visit (typically every 2-4 weeks initially).
  • Renal function: In patients with moderate to severe renal impairment, monitor serum creatinine and adjust dose if necessary.

Storage and Handling

  • Store the pills at room temperature (15-25 °C), away from moisture and direct sunlight.
  • Keep the container tightly closed and out of reach of children.
  • Dispose of unused tablets according to local pharmacy take-back programmes or the instructions on the package insert.

Medication-Specific Glossary

Benzodiazepine
A class of psychoactive drugs that enhance GABA activity, producing anxiolytic, sedative, muscle-relaxant, and anticonvulsant effects.
Anxiolytic
A medication that reduces anxiety without causing substantial sedation.
GABA (Gamma-Aminobutyric Acid)
The chief inhibitory neurotransmitter in the central nervous system; it dampens neuronal excitability.

Medical Disclaimer

This article provides educational information about tofisopam and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Tofisopam is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
Categories
Hoe kunt u Antivirale middelen bestellen - Aciclovir bestellen Order medications for Heartburn GERD Tablets: - Esomeprazole Price