Buy Temovate
Temovate

7.79
Temovate (clobetasol propionate) is a high-potency corticosteroid used to treat various inflammatory skin conditions. It helps adults manage symptoms such as itching, redness, and swelling associated with dermatitis or psoriasis. The formulation works by reducing the immune response in the skin to effectively calm irritation.


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Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Clobetasol Propionate
Reference Brand
Dermovate
Manufacturer
GlaxoSmithKline
Product Form
Cream, Ointment, Scalp Application
Regulatory Classification
Rx
Primary Category
Skin Care, Anti-inflammatory
Product Category
Corticosteroids, potent (group IV)
Pharmacological Class
Corticosteroids
Manufacturer Description
A very strong steroid treatment used on the skin to reduce inflammation and irritation in severe skin conditions.
Mechanism of Action
It is a highly potent steroid that reduces the swelling, itching, and redness associated with various skin conditions by inhibiting the release of inflammatory substances in the skin cells.
Route of Administration
Topical
Onset Time
Within a few days
Duration
Variable based on skin absorption
Contraindications
Untreated skin infections, Rosacea, Acne vulgaris, Perioral dermatitis, Itching without inflammation
Severe Adverse Events
Blurry vision, Weight gain in the face, Adrenal suppression, Severe allergic reaction
Common Side Effects
Burning sensation, Stinging, Skin redness
Uncommon Side Effects
Thinning of the skin, Stretch marks, Changes in skin colour, Increased hair growth
Drug Interactions
Ritonavir, Itraconazole
Pregnancy Safety Warnings
Use with caution; should only be used if the potential benefit justifies the risk.
Age Restrictions
Not recommended for children under 1 year of age.
Storage Guidelines
Store below 30°C. Keep the cap tightly closed.
Related Products
Betamethasone, Hydrocortisone, Eumovate

Temovate FAQ

Can I use Temovate 0.05% on my scalp?

Yes, the product can be applied to scalp lesions of psoriasis or seborrhoeic dermatitis. Use a small amount and massage gently; avoid excessive application to minimize systemic absorption.

What should I do if I accidentally apply Temovate 0.05% to a large area?

Stop application immediately and contact a healthcare professional. Large-area use may increase the risk of systemic side effects, and the clinician may advise monitoring cortisol levels.

Is Temovate 0.05% safe for use on the face?

It may be used on facial skin for short periods if the prescriber deems it necessary, but the face is more prone to atrophy. Prefer lower-potency steroids for facial lesions when possible.

How does Temovate 0.05% differ from over-the-counter hydrocortisone creams?

Temovate is a very high-potency corticosteroid, whereas OTC hydrocortisone products are low-potency. The stronger anti-inflammatory effect of Temovate makes it suitable for resistant conditions but also carries higher risk of side effects.

Can I wash the treated area after applying the cream?

Do not wash or rinse the area for at least 2 hours after application to allow optimal absorption.

Will Temovate 0.05% show up on drug tests for athletes?

Topical clobetasol is not typically screened in standard anti-doping tests, but high-dose or extensive use could be detectable. Athletes should consult their governing body’s medication guidelines.

What imprint or identifying marks are on the tube?

UK-marketed Temovate tubes often display the brand name, strength “0.05 %”, and the manufacturer’s logo. Specific batch numbers and expiry dates are printed on the label.

Are there any environmental concerns when disposing of the tube?

Do not flush the medication down the toilet. Dispose of the empty tube and any remaining product according to local pharmacy-take-back programmes or follow the “Do not crush” instructions on the label.

Can I use Temovate 0.05% while pregnant?

Use only if the potential benefit outweighs the risk. Discuss with a healthcare provider; topical corticosteroids can cross the placenta in small amounts, and safer alternatives are preferred when possible.

How long does a 15 g tube typically last?

With once-daily application to a limited area, a 15 g tube usually lasts 2-3 weeks. Usage varies with the size of the treated surface and amount applied per dose.

Temovate 0.05%: Generic Medication Overview

Temovate 0.05% contains the active ingredient clobetasol propionate, a synthetic corticosteroid used for skin conditions that require potent anti-inflammatory and immunosuppressive treatment. In the United Kingdom, it is classified as a prescription-only medicine (POM) and is supplied in a tube containing either 15 g or 30 g of product. The medication belongs to the skin-care therapeutic class and is marketed under the brand name Temovate, among other possible brand names.

How Temovate 0.05% Works in the Body

Clobetasol propionate is a high-potency topical corticosteroid. It penetrates the skin and binds to intracellular glucocorticoid receptors, forming a complex that migrates to the cell nucleus. This complex modulates gene transcription, resulting in:

  • Reduced production of inflammatory cytokines (e.g., interleukins, tumor-necrosis factor-α)
  • Decreased migration of immune cells to the skin surface
  • Suppression of vasodilation and edema

These actions lead to rapid relief of redness, swelling, and itching. The drug’s onset of action is typically within a few hours, with peak effects observed after several days of consistent use. Because it is applied topically, systemic absorption is limited, but prolonged use on large surface areas can result in measurable plasma levels.

Conditions Treated by Temovate 0.05%

Temovate 0.05% is approved by the MHRA for short-term treatment of the following dermatological conditions:

  • Psoriasis (plaque, palmoplantar, scalp)
  • Seborrhoeic dermatitis
  • Eczema (including atopic dermatitis) that is resistant to milder steroids
  • Discoid lupus erythematosus (skin lesions)
  • Lichen planus
  • Pruritus associated with inflammatory skin disease

The medication is intended for adult and adolescent patients (≥12 years) when a high-potency corticosteroid is clinically justified.

Evidence-Based Off-Label Uses

Research has explored clobetasol propionate for several off-label indications, though none are formally approved in the UK:

  • Keloid and hypertrophic scar management - case series suggest benefit when applied once daily for limited periods.
  • Oral lichen planus - small open-label studies report symptomatic relief with topical application to mucosal lesions.

Disclaimer: Off-label use requires medical supervision and individualized risk assessment.

Who Should (Not) Use Temovate 0.05%?

Absolute Contraindications

  • Known hypersensitivity to clobetasol propionate or any excipients in the formulation.
  • Viral skin infections (e.g., herpes simplex, varicella) in the area to be treated.
  • Untreated fungal, bacterial, or parasitic infections of the target skin.

Relative Contraindications

  • Pregnancy - systemic absorption may affect fetal development; use only if clearly needed.
  • Lactation - limited data; avoid application to the breast area.
  • Severe hepatic impairment - may increase systemic exposure.
  • Children under 12 years - high-potency steroids are generally avoided in this age group.

Special Populations

  • Elderly patients - skin is thinner; use the lowest effective amount and limit duration.
  • Patients with extensive skin atrophy - monitor closely for worsening thinning.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Skin irritation or burning - usually mild and transient.
  • Dryness or peeling of the treated area.
  • Folliculitis (inflammatory hair-follicle reaction).

Serious Adverse Events

  • Skin atrophy (thinning, striae, telangiectasia) with prolonged use.
  • Hypothalamic-pituitary-adrenal (HPA) axis suppression - may manifest as fatigue, hypotension, or adrenal insufficiency after extensive application.
  • Local secondary infections (bacterial, fungal) due to immunosuppression.
  • Glaucoma or cataract formation if applied near the eyes.

If any of these serious signs occur, discontinue the medication and seek immediate medical attention.

Drug Interactions

  • Systemic corticosteroids - concurrent use may increase the risk of HPA-axis suppression.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) - can raise systemic levels when large skin areas are treated.
  • Other topical immunosuppressants (e.g., tacrolimus) - may have additive effects on local immunity.

Food and Lifestyle Interactions

  • No known food interactions.
  • Alcohol does not affect topical absorption but may exacerbate liver disease, which can alter systemic handling of the drug.
  • Driving or operating machinery - no impairment expected.

Patients should inform their healthcare provider of all medicines, supplements, and herbal products before starting Temovate 0.05%.

How to Take Temovate 0.05%

  • Standard regimen: Apply a thin film to the affected skin once daily (usually in the evening) for up to 2 weeks, unless directed otherwise by a prescriber.
  • Application tips:
  • Wash hands before and after use.
  • Gently cleanse and pat the skin dry; avoid vigorous rubbing.
  • Use only the amount needed to cover the lesion; do not exceed the prescribed quantity.
  • Special populations:
  • Renal or hepatic impairment: No dosage adjustment required for topical use, but monitor for systemic effects if large areas are treated.
  • Elderly: Limit treatment duration and surface area to minimise atrophy.
  • Missed dose: Apply at the next appropriate time; do not double the dose.
  • Overdose: Signs may include extensive skin thinning, systemic corticosteroid effects (e.g., weight gain, hypertension). Seek urgent medical care; treatment is supportive.
  • Discontinuation: Abrupt cessation after prolonged use may precipitate rebound inflammation. Tapering-gradually reducing frequency-may be advised by a clinician.

Dosing must be individualized; the information above reflects typical practice for the 0.05 % strength available in 15 g and 30 g tubes.

Monitoring and Follow-Up

  • Clinical review after 1-2 weeks to assess response and skin integrity.
  • If treatment exceeds 2 weeks or involves >10 % of body surface area, consider:
  • Baseline and periodic morning serum cortisol to evaluate HPA-axis function.
  • Skin assessment for signs of atrophy, striae, or secondary infection.
  • Patients with diabetes should monitor blood glucose, as systemic absorption may affect glycaemic control.

Storage and Handling

  • Store the tube at room temperature (15-25 °C), away from direct sunlight and moisture.
  • Keep the container tightly closed when not in use.
  • Do not freeze.
  • Discard any product that has changed colour, consistency, or exceeds the expiration date printed on the label.
  • Keep out of reach of children; the tube is child-resistant.

Medication-Specific Glossary

Glucocorticoid Receptor
A cellular protein that, when bound by corticosteroids, influences gene transcription to reduce inflammation.
Potency (Topical Corticosteroids)
A classification that reflects the strength of anti-inflammatory action; clobetasol propionate is a very high-potency agent.
HPA-Axis Suppression
Reduced activity of the hypothalamic-pituitary-adrenal axis, potentially leading to adrenal insufficiency when systemic corticosteroid levels become significant.
Skin Atrophy
Thinning of the epidermis and dermis, often manifesting as easy bruising, stretch marks, or translucency.
Rebound Dermatitis
Flare-up of the original skin condition after abrupt discontinuation of a potent topical steroid.

Medical Disclaimer

This article provides educational information about Temovate 0.05% and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Temovate is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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