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Symbicort Powder

46.75
Symbicort Powder (budesonide/formoterol fumarate dihydrate) is a combination inhaler used for the maintenance treatment of asthma and COPD. The corticosteroid reduces airway inflammation while the long-acting beta-agonist relaxes muscles in the lungs, facilitating easier breathing and preventing future respiratory symptoms for adult patients.


Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Budesonide, Formoterol Fumarate Dihydrate
Reference Brand
Symbicort Turbohaler
Manufacturer
AstraZeneca
Product Form
Turbohaler
Regulatory Classification
Rx
Primary Category
Asthma Management, COPD
Product Category
Drugs for obstructive airway diseases, Adrenergics in combination with corticosteroids
Pharmacological Class
Corticosteroid and Long-acting Beta Agonist (LABA)
Manufacturer Description
A 2-in-1 inhaler commonly used to both prevent asthma symptoms and maintain clear airways in chronic lung diseases.
Mechanism of Action
Budesonide reduces inflammation in the lungs, while Formoterol relaxes the airway muscles. Together they provide both long-term control and a maintenance effect to keep airways open.
Route of Administration
Inhalation
Onset Time
1-3 minutes
Duration
12 hours
Contraindications
Hypersensitivity to budesonide or formoterol, Hypersensitivity to lactose
Severe Adverse Events
Pneumonia (in COPD patients), Blurred vision, Growth retardation in children (prolonged use), Adrenal suppression
Common Side Effects
Mild throat irritation, Hoarseness, Oral thrush
Uncommon Side Effects
Palpitations, Tremor, Headache, Rapid pulse
Drug Interactions
Ketoconazole, Beta-blockers, Quinidine, MAOIs
Pregnancy Safety Warnings
Consult a doctor; only use if clearly necessary.
Age Restrictions
Varies by dose strength; generally 6 or 12 years and older
Storage Guidelines
Keep the cap on. Store in a dry place below 30°C.
Related Products
Fostair, Seretide, Relvar Ellipta

Symbicort Powder FAQ

Can Symbicort Powder be used to treat an acute asthma attack?

No. Symbicort is a maintenance inhaler designed for regular use to control asthma. For sudden breathlessness you should use a short-acting bronchodilator such as salbutamol.

How quickly does Symbicort start working after inhalation?

Formoterol produces bronchodilation within a few minutes, while budesonide’s anti-inflammatory effects build up over several days. Patients often notice improved ease of breathing within the first week of regular use.

What is the best way to prevent oral thrush while using Symbicort?

Rinse your mouth with water and spit it out after each inhalation. This removes residual steroid that can promote fungal overgrowth. Maintaining good oral hygiene also helps.

Can I take other inhaled asthma medicines together with Symbicort?

Yes, a short-acting reliever (e.g., salbutamol) is usually prescribed alongside Symbicort for rescue use. Other controller medications should only be added after a prescriber’s evaluation to avoid duplicate dosing.

I missed my evening dose-what should I do?

If you realize the missed dose more than six hours later, take it as soon as possible. If the next scheduled dose is imminent, skip the missed dose and resume the regular schedule. Do not double the dose.

Is Symbicort safe to use during pregnancy?

Budesonide is classified as Category B in the UK, indicating limited evidence of risk in humans. It may be used if the clinical benefit outweighs potential risks. Pregnant patients should discuss the decision with their obstetrician.

Do I need to clean the Symbicort inhaler?

Yes. Wipe the mouthpiece with a clean, dry cloth regularly to remove powder residue. Do not wash the device with water, as moisture can damage the inhaler mechanism.

Can I travel with Symbicort on an airplane?

You may carry Symbicort in both hand luggage and checked baggage. Keep it in its original packaging, and inform security if asked. The inhaler does not contain lithium batteries and is not prohibited.

Will using Symbicort affect a drug test for sports?

Budesonide and formoterol are not prohibited substances in most sporting regulations, but some anti-doping agencies have thresholds for inhaled β₂-agonists. Athletes should disclose inhaler use and consult their sport’s governing body.

How long can an opened Symbicort inhaler be stored before it expires?

The dose counter indicates remaining doses; once it reaches zero, the inhaler should be discarded regardless of the calendar date. Generally, a DPI remains effective for 30 days after opening, but always follow the manufacturer’s stated expiry on the package.

What is Symbicort Powder?

Symbicort Powder is a prescription inhaler that combines two active ingredients-budesonide and formoterol fumarate dihydrate-into a single dry-powder inhaler (DPI). Budesonide is an inhaled corticosteroid that reduces airway inflammation, while formoterol is a long-acting β₂-agonist (LABA) that relaxes airway smooth muscle. In the United Kingdom the product is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) and is available only with a prescription from a qualified prescriber. The inhaler delivers a fixed dose of 160 µg budesonide / 4.5 µg formoterol per inhalation.

How Symbicort Powder Works in the Body

  • Budesonide (corticosteroid)

  • Enters airway cells and binds glucocorticoid receptors.

  • Switches off inflammatory genes and promotes the production of anti-inflammatory proteins.

  • Reduces swelling, mucus production, and the responsiveness of the airway to triggers.

  • Formoterol (LABA)

  • Stimulates β₂-adrenergic receptors on airway smooth muscle.

  • Increases cyclic-AMP, leading to rapid muscle relaxation (onset within minutes) and a sustained bronchodilatory effect that lasts about 12 hours.

  • Combined effect

  • The anti-inflammatory action of budesonide lowers the underlying airway hyper-responsiveness, while formoterol provides quick and long-lasting relief from bronchoconstriction.

  • Together they improve lung function, reduce the frequency of asthma symptoms, and help prevent exacerbations.

Conditions Treated by Symbiotic Powder

Symbicort Powder is approved in the UK for:

  • Maintenance treatment of asthma in adults and adolescents (≥12 years).
  • Used regularly to control chronic symptoms and to lower the risk of severe attacks.
  • Prevention of exercise-induced bronchoconstriction when prescribed as part of an overall asthma management plan.

Symbicort is not intended for immediate relief of an acute asthma attack; a separate short-acting bronchodilator (e.g., salbutamol) should be kept on hand for rescue use.

Patient Suitability and Contraindications

Who Should Use Symbicort Powder?

  • Individuals with a confirmed diagnosis of asthma who need a controller medication to maintain symptom control.
  • Patients who can handle a twice-daily inhaler regimen and who are able to use a dry-powder inhaler correctly.

Absolute Contraindications

  • Known hypersensitivity to budesonide, formoterol, any excipients in the inhaler, or other inhaled corticosteroids/LABAs.
  • Patients who have experienced a paradoxical bronchospasm with a β₂-agonist.

Relative Contraindications / Precautions

  • Cardiovascular disease (e.g., arrhythmia, angina) - formoterol may increase heart rate.
  • Hyperthyroidism, diabetes, or hypokalaemia - β₂-agonists can aggravate these conditions.
  • Pregnancy & lactation - use only if the potential benefit outweighs the risk; budesonide is classified as Category B in the UK.
  • Severe liver impairment - may affect budesonide metabolism.

Special Populations

  • Children under 12 years - not indicated in the UK for this age group.
  • Elderly - start with the lowest effective dose and monitor for cardiovascular side effects.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Oral thrush (candidiasis) - reported in up to 10 % of users.
  • Hoarseness or voice changes.
  • Dry mouth, throat irritation, or cough after inhalation.

Rinsing the mouth with water (without swallowing) after each dose reduces the risk of thrush.

Serious Adverse Events

  • Paradoxical bronchospasm - sudden worsening of breathing after inhalation.
  • Adrenal suppression - especially with high-dose or prolonged corticosteroid use; monitor cortisol levels if clinically indicated.
  • Growth suppression in children and adolescents (not applicable here but relevant for paediatric use).
  • Cardiovascular effects - palpitations, tachycardia, or hypertension.
  • Pneumonia - observed more frequently in patients with COPD (off-label use).

Drug Interactions

  • β-blockers (e.g., propranolol) may diminish the bronchodilator effect of formoterol.
  • Other sympathomimetic agents (e.g., epinephrine) can increase the risk of tachyarrhythmia.
  • Strong CYP3A4 inhibitors (ketoconazole, ritonavir) may raise budesonide plasma concentrations, potentially heightening systemic steroid effects.
  • Diuretics (e.g., furosemide) can exacerbate hypokalaemia when combined with LABAs.

Food and Lifestyle Interactions

  • No specific food restrictions, but avoid inhaling immediately after a heavy meal if you experience reflux-related cough.
  • Alcohol does not significantly interfere with Symbicort, but excessive intake may worsen asthma control indirectly.
  • Operating heavy machinery is generally safe, though patients experiencing tremor or palpitations should exercise caution.

How to Take Symbicort Powder

  • Standard dosing - One inhalation (160 µg budesonide / 4.5 µg formoterol) twice daily, once in the morning and once in the evening.
  • Administration steps
  1. Open the inhaler and turn the cap to load a dose.
  2. Breathe out fully, away from the mouthpiece.
  3. Place the inhaler between the lips, seal firmly, and inhale rapidly and deeply.
  4. Hold the breath for about 10 seconds, then exhale slowly.
  5. Rinse the mouth with water and spit out the water; do not swallow.
  • Missed dose - If you remember a missed dose more than 6 hours later, take it as soon as possible. If the next scheduled dose is due within a short time, skip the missed dose-do not double up.

  • Overdose - Signs may include severe tremor, rapid heart rate, nausea, or dizziness. Seek medical assistance promptly; treatment is supportive and may involve bronchodilator antagonists if severe bronchospasm occurs.

  • Discontinuation - Long-term high-dose inhaled corticosteroids may require a gradual taper to avoid adrenal insufficiency. Follow your prescriber’s guidance when stopping or reducing therapy.

Monitoring and Follow-Up

  • Asthma control review - Every 3-6 months, assess symptom frequency, rescue inhaler use, and exacerbation history.
  • Lung function testing - Spirometry or peak-flow monitoring helps gauge treatment effectiveness.
  • Side-effect surveillance - Look for oral thrush, hoarseness, or signs of systemic steroid exposure (e.g., bruising, poor wound healing).
  • Growth monitoring - In patients under 18 years, periodic height measurements are recommended.
  • Inhaler technique check - Incorrect use reduces drug delivery; ensure patients are reviewed regularly.

Storage and Handling

  • Keep the inhaler at room temperature (15-30 °C), protected from moisture and direct sunlight.
  • Do not refrigerate or freeze the device.
  • Store out of reach of children and pets.
  • Once the dose counter reaches 0, discard the inhaler-even if a few doses appear remaining.
  • Replace the inhaler as per the manufacturer’s expiry date; use a new device if the powder appears clumped or the inhaler does not click.

Medication-Specific Glossary

Budesonide
An inhaled corticosteroid that suppresses airway inflammation by binding glucocorticoid receptors in lung tissue.
Formoterol
A long-acting β₂-agonist that relaxes airway smooth muscle, providing bronchodilation that lasts up to 12 hours.
Dry Powder Inhaler (DPI)
A device that releases a fine powder formulation of medication, which the patient inhales with a rapid, deep breath.
Paradoxical Bronchospasm
An unexpected worsening of airway narrowing after inhalation of a bronchodilator, requiring immediate medical review.
Adrenal Suppression
Reduced production of endogenous cortisol due to prolonged exposure to systemic corticosteroids.

Medical Disclaimer

This article provides educational information about Symbicort Powder and is not a substitute for professional medical advice. Treatment decisions, including the use of any medication for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Symbicort Powder is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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