Yes. Prometrium tablets are classified as prescription medication, so you should carry the original prescription label and a copy of the prescription. Security scanners do not detect pills, but you may be asked to present documentation at customs.
The 100 mg tablet typically bears the imprint “PROM 100” and the 200 mg tablet “PROM 200.” Imprints can vary slightly by manufacturer, so always verify the appearance against the pharmacy label.
Progesterone is a naturally occurring hormone and is not listed as a prohibited substance by the World Anti-Doping Agency (WADA). However, athletes should disclose any hormonal medication to their sport’s medical authority, as some formulations may contain trace additives.
Prometrium delivers bioidentical progesterone, which has the same molecular structure as the hormone produced by the body. Synthetic progestins have altered structures, may bind different receptors, and can have distinct side-effect profiles.
No. The tablets are micronized to ensure consistent absorption; crushing or splitting can alter the drug’s pharmacokinetics and increase side-effects. If a different dose is needed, the prescriber should change the prescribed strength.
A rash may signal an allergic reaction. Discontinue the medication and seek medical assessment promptly. Do not restart without a formal evaluation.
Yes. Moisture can degrade the tablet coating. Keep the bottle tightly closed, store it in a dry place, and avoid bathrooms or kitchens where humidity is high.
Progesterone micronized tablets are available from several manufacturers under different brand names. The active ingredient and dosage strengths are equivalent, but patients should confirm equivalence with their pharmacist.
When used for luteal-phase support, cycle regularisation may be observed within one to three menstrual cycles, but individual responses vary. Ongoing monitoring by a clinician is essential.
Progesterone supplementation does not typically reduce the contraceptive efficacy of combined oral contraceptives. However, clinicians may adjust dosing or timing to avoid overlapping hormonal peaks. Always discuss concurrent hormonal therapies with your prescriber.
Prometrium is a prescription medication that contains the natural hormone progesterone as its active ingredient. It is supplied as an oral pill in strengths of 100 mg and 200 mg. In the United Kingdom, Prometrium is classified as a prescription-only medicine (POM) and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). It is used primarily in women’s health to replace or supplement progesterone that the body would normally produce.
Progesterone is a steroid hormone produced by the ovaries after ovulation and, during pregnancy, by the placenta. It prepares the lining of the uterus (the endometrium) for implantation of a fertilised egg and helps maintain a pregnancy. When taken as a micronized oral pill, progesterone is absorbed through the gastrointestinal tract, enters the bloodstream, and binds to progesterone receptors in target tissues.
Key pharmacological points:
Prometrium is approved in the UK for the following indications:
These indications are supported by clinical guidelines and the product’s Summary of Product Characteristics (SPC) approved by the MHRA.
If any of the above conditions apply, a healthcare professional must assess the risk-benefit profile before initiating therapy.
These reactions are typically mild, transient, and often improve with continued therapy.
If any serious symptom occurs, stop the medication and seek immediate medical care.
Patients should inform their prescriber of all medicines, over-the-counter products, and herbal supplements they are taking.
The exact regimen-including the number of days per cycle and whether treatment is continuous or cyclic-must be determined by a prescribing clinician based on the individual’s health status and therapeutic goal.
If a dose is missed, take it as soon as it is remembered unless it is close to the time of the next scheduled dose. Do not double the dose.
Symptoms of an overdose may include excessive sedation, profound dizziness, or severe nausea. Seek urgent medical attention. There is no specific antidote; treatment is supportive.
For HRT, clinicians often recommend a gradual taper rather than abrupt cessation to minimise withdrawal symptoms such as hot flashes or mood swings. Follow the prescriber’s instructions for any dose reduction schedule.
Patients should attend all scheduled appointments and report any new symptoms promptly.
Micronized - The process of reducing progesterone particles to a very small size, enhancing its oral absorption.
Endometrial hyperplasia - A thickening of the uterine lining that can occur with unopposed estrogen; progesterone counteracts this effect.
Luteal phase - The post-ovulation segment of the menstrual cycle, lasting roughly 14 days, during which progesterone prepares the endometrium for possible implantation.
Bioavailability - The proportion of an orally administered drug that reaches systemic circulation in an active form; micronized progesterone has relatively good bioavailability compared with non-micronized forms.
This article provides educational information about Prometrium and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.
