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Phoslo

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Phoslo (calcium acetate) is a phosphate binder primarily used by individuals with kidney concerns to maintain healthy mineral balance. By binding to dietary phosphorus in the digestive tract, it prevents excess absorption, supporting long-term bone health and cardiovascular stability.


Ingredient
Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Calcium Acetate
Reference Brand
Phosex
Manufacturer
Fresenius Medical Care
Product Form
Tablet, Capsule
Regulatory Classification
Rx
Primary Category
Phosphate Binder
Product Category
Alimentary tract and metabolism, Drugs for treatment of hyperkalaemia and hyperphosphataemia
Pharmacological Class
Calcium salts
Manufacturer Description
A mineral supplement used to control high phosphate levels in patients with severe kidney disease.
Mechanism of Action
It works by binding to phosphorus found in the foods you eat. This bound phosphorus is then eliminated from the body through bowel movements, preventing it from being absorbed into the bloodstream, which is vital for patients with reduced kidney function.
Route of Administration
Oral
Onset Time
Immediate action in the gut
Duration
Duration of the digestive process
Contraindications
Hypercalcaemia, Kidney stones containing calcium, Hypophosphataemia
Severe Adverse Events
Confusion, Irregular heartbeat, Muscle weakness, Severe constipation
Common Side Effects
Mild nausea, Constipation, Loss of appetite
Uncommon Side Effects
Vomiting, Stomach pain, Dry mouth
Drug Interactions
Ciprofloxacin, Tetracycline antibiotics, Levothyroxine, Digoxin
Pregnancy Safety Warnings
Generally considered safe under medical supervision during pregnancy.
Age Restrictions
Safety and effectiveness in children not established
Storage Guidelines
Store at room temperature in a dry place.
Related Products
Sevelamer, Lanthanum carbonate, Calcium carbonate

Phoslo FAQ

Can I take Phoslo while traveling abroad?

Yes, you may travel with Phoslo, but keep the tablets in their original packaging with the label visible. In some countries, calcium supplements are considered over-the-counter, yet a prescription label helps avoid customs delays. Carry a copy of the prescription or a doctor’s note if you are traveling with a large supply.

Will Phoslo appear on a standard drug test for employment or sport?

Calcium acetate is a nutritional supplement and is not listed among substances prohibited by workplace or sports anti-doping agencies. It generally does not trigger a positive result on routine drug screenings.

What does the imprint on a Phoslo tablet look like?

Phoslo tablets are typically imprinted with the brand name “PHOSLO” followed by the dosage strength “667”. If you receive tablets with a different imprint, verify the medication with your pharmacist.

How does Phoslo differ from other calcium supplements such as calcium carbonate?

Calcium acetate provides calcium in a form that also has mild phosphate-binding properties, whereas calcium carbonate is primarily a calcium source with a higher elemental calcium content per milligram. The choice between them depends on individual health needs, gastrointestinal tolerance, and any concurrent renal considerations.

Is it safe to combine Phoslo with vitamin D supplements?

Vitamin D enhances calcium absorption, so co-administration is common and generally safe. However, excess vitamin D together with high calcium intake can increase the risk of hypercalcaemia; dosing should follow a healthcare professional’s guidance.

Can I crush or split a Phoslo tablet if I have difficulty swallowing?

Phoslo tablets are formulated to be swallowed whole. Crushing or splitting may alter the release profile and increase gastrointestinal irritation. Discuss alternative formulations with your prescriber if swallowing tablets is problematic.

What should I do if I experience persistent constipation while taking Phoslo?

Increase dietary fiber, hydrate adequately, and consider a mild stool softener after consulting your pharmacist. If constipation continues, your prescriber may adjust the calcium dose or suggest a different calcium salt.

Does Phoslo interact with antacids or proton-pump inhibitors?

Antacids containing aluminum or magnesium can interfere with calcium absorption. Proton-pump inhibitors may reduce stomach acidity, modestly affecting calcium acetate dissolution. Stagger the timing of these medications by at least 2 hours when possible.

Are there any price or patent considerations for Phoslo in the UK?

Phoslo is a branded product and may be priced higher than generic calcium acetate tablets. Once the original patent expires, generic versions become available at reduced cost. Pharmacy enquiries can provide current pricing and any available patient support schemes.

What is Phoslo?

Phoslo is a prescription medication marketed in the United Kingdom that contains calcium acetate as its sole active ingredient. It is supplied as a 667 mg pill intended to help adults meet their calcium needs and support normal bone health. Calcium acetate belongs to the broader class of calcium-based supplements and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK. The tablet is typically prescribed by a GP or a specialist when a clinician determines that additional calcium is required, for example in individuals with low dietary intake, certain gastrointestinal disorders, or increased physiological demand.

How Phoslo Works in the Body

Calcium acetate provides a source of calcium ions that are released after the tablet dissolves in the stomach. The released calcium is absorbed primarily in the small intestine, where it becomes part of the elemental calcium pool that circulates in the bloodstream. Calcium is a critical mineral for:

  • Bone mineralization - it combines with phosphate to form hydroxyapatite, the crystal that gives bone its strength and rigidity.
  • Cellular signalling - calcium participates in nerve transmission, muscle contraction, and hormone release.

When calcium intake is adequate, the body can maintain a balance between bone formation (by osteoblasts) and bone resorption (by osteoclasts). Phoslo therefore contributes to the maintenance of normal bone remodeling cycles, helping to preserve bone density and reduce the risk of osteoporosis-related fractures in adults who are calcium-deficient.

Conditions Treated by Phoslo

In the UK, Phoslo is approved for the treatment of calcium deficiency and for maintenance of bone health in adult patients who require supplemental calcium. Typical clinical situations include:

  • Adults with low dietary calcium intake (e.g., restrictive diets, malabsorption syndromes).
  • Post-menopausal women or older men at increased risk of osteoporosis.
  • Patients on long-term glucocorticoid therapy, which can increase calcium loss from bone.

The medication is intended to be used as part of a comprehensive bone-health strategy that also includes adequate vitamin D, regular weight-bearing exercise, and lifestyle measures such as smoking cessation.

Evidence-Based Off-Label Uses

While Phoslo’s primary indication is calcium supplementation for bone health, calcium acetate is also employed in chronic kidney disease (CKD) to bind dietary phosphate. This off-label application is supported by clinical studies showing that calcium acetate can reduce serum phosphate levels, thereby helping to control secondary hyperparathyroidism in CKD patients. Because this use is not formally approved for Phoslo in the UK, it should only be considered under the direct supervision of a nephrologist, with regular monitoring of calcium and phosphate balance.

Off-label use requires medical supervision and an individualized risk assessment.

Who Should (and Should Not) Use Phoslo?

Ideal Candidates

  • Adults (≥ 18 years) with documented low calcium intake or low serum calcium.
  • Individuals at risk of osteoporosis who have been advised to increase calcium intake.
  • Patients who can swallow tablets whole and have no contraindicating medical conditions.

Absolute Contraindications

  • Known hypersensitivity to calcium acetate or any excipients in the tablet.
  • Existing hypercalcaemia (serum calcium above the normal reference range).
  • Severe renal impairment (eGFR < 15 mL/min/1.73 m²) when phosphate binding is not intended.

Relative Contraindications & Special Populations

  • Pregnancy and lactation: Calcium is essential, but dosing should be guided by a healthcare professional to avoid excess calcium.
  • Sarcoidosis or other granulomatous diseases: These conditions can predispose to hypercalcaemia.
  • History of kidney stones: Calcium supplementation may increase stone risk; careful assessment is required.
  • Elderly patients: Reduced renal function may necessitate lower doses or closer monitoring.

If any of these conditions apply, the prescribing clinician will weigh the benefits against potential risks before initiating therapy.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Gastro-intestinal discomfort (up to 10 % of users) - mild stomach ache, bloating.
  • Constipation - reported in up to 5 % of patients; increasing fluid intake can help.
  • Nausea or mild indigestion - usually transient and resolves with continued use.

Serious Adverse Events

  • Hypercalcaemia - symptoms may include excessive thirst, frequent urination, confusion, and cardiac arrhythmias. Immediate medical attention is required.
  • Renal calculi (kidney stones) - rare but more likely in patients with a history of stone disease.
  • Severe allergic reactions - rash, swelling, or difficulty breathing; treat as an emergency.

Drug Interactions

  • Tetracycline and quinolone antibiotics - calcium can chelate these agents, markedly reducing their absorption. Separate dosing by at least 2 hours.
  • Bisphosphonates (e.g., alendronate) - similar chelation effect; administer on an empty stomach and wait 30 minutes before taking calcium.
  • Iron supplements and levothyroxine - calcium reduces oral bioavailability; stagger administration.
  • Thiazide diuretics - may potentiate calcium retention and increase hypercalcaemia risk.

Patients should provide their prescriber with a full medication list, including over-the-counter products and herbal supplements.

Food and Lifestyle Interactions

  • Take with meals - calcium acetate is best absorbed when taken with food, which also reduces gastrointestinal upset.
  • Avoid excessive dairy in conjunction with high-dose calcium acetate, as this may increase calcium load unnecessarily.
  • Alcohol - moderate consumption is acceptable, but heavy drinking can affect bone metabolism and calcium balance.
  • Driving or operating machinery - calcium acetate does not impair cognition; however, severe hypercalcaemia can cause drowsiness or confusion.

If you are uncertain about any interaction, discuss it with a pharmacist or prescriber.

How to Take Phoslo

Standard Dosing

  • Strength: 667 mg calcium acetate per tablet.
  • Typical regimen: The prescribing information often targets a total daily calcium intake of 1000-1300 mg of elemental calcium. Depending on individual requirements, this may be achieved with one or two tablets daily, taken with meals.

Precise dosing must be individualized by the prescribing clinician based on dietary calcium intake, serum calcium levels, and overall health status.

Adjustments for Special Populations

  • Renal impairment: Lower doses or extended dosing intervals may be recommended to avoid calcium accumulation.
  • Elderly patients: Start with the lowest effective dose and monitor serum calcium regularly.
  • Pregnant or lactating women: Dose adjustments are made case-by-case, ensuring both maternal and fetal calcium needs are met without excess.

Administration Instructions

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or split the tablet unless explicitly advised.
  • Take the medication with food to improve absorption and lessen gastrointestinal side effects.
  • Store tablets in the original container, tightly closed, at room temperature (≤ 30 °C), protected from moisture and light.

Missed Dose

If you forget a dose, take it as soon as you remember provided there is at least a 4-hour gap before the next scheduled dose. Do not double up to make up for the missed tablet.

Overdose Management

Symptoms of calcium acetate overdose may include severe nausea, vomiting, muscle weakness, and pronounced hypercalcaemia. If overdose is suspected, seek emergency medical care; treatment may involve intravenous hydration, diuretics, and, in severe cases, dialysis.

Discontinuation

Phoslo can be stopped without tapering in most adults. However, abrupt cessation after long-term high-dose use may lead to a transient dip in calcium levels; periodic monitoring after discontinuation is advisable, especially in patients with osteoporosis.

Monitoring and Follow-Up

  • Serum calcium and phosphate - measured at baseline and periodically (e.g., every 3-6 months) to ensure levels remain within the normal range.
  • Renal function (eGFR, serum creatinine) - especially in patients with known kidney disease or those on high-dose calcium.
  • Urinary calcium excretion - may be assessed in individuals with a history of kidney stones.
  • Bone mineral density (DEXA scan) - recommended for patients at high risk of osteoporosis to evaluate treatment effectiveness.

Regular follow-up appointments enable the clinician to adjust the dose, address side effects, and reinforce adherence.

Storage and Handling

  • Keep the tablets out of reach of children and pets.
  • Store at room temperature (15-30 °C), away from direct sunlight and moisture.
  • Do not use tablets that are discolored, cracked, or past the expiry date shown on the packaging.
  • Dispose of unused medication according to the UK Medicines Disposal Advisory Service (e.g., return to a pharmacy).

Medication-Specific Glossary

Bone Remodeling
The continuous process of bone tissue resorption by osteoclasts and formation by osteoblasts, essential for maintaining bone strength and calcium homeostasis.
Hypercalcaemia
An abnormally high concentration of calcium in the blood (typically > 2.6 mmol/L), which can cause neurological, cardiac, and renal complications.
Elemental Calcium
The amount of calcium ion that becomes available for physiological use after a calcium compound is ingested and metabolized.
Phosphate Binder
A medication that binds dietary phosphate in the gastrointestinal tract, reducing its absorption; calcium acetate serves this role in chronic kidney disease.

Medical Disclaimer

This article provides educational information about Phoslo and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Phoslo is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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