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Lanoxin

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Lanoxin (digoxin) is a cardiac glycoside used to treat heart failure and certain types of irregular heartbeats, such as atrial fibrillation. It works by increasing the force of the heart muscle contractions and regulating the heart rate, helping the heart pump blood more efficiently throughout the body.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Digoxin
Reference Brand
Digoxin
Manufacturer
Aspen
Product Form
Tablet, Oral solution, Injection
Regulatory Classification
Rx
Primary Category
Heart Rhythm Management, Heart Failure Treatment
Product Category
Cardiac therapy, Cardiac glycosides
Pharmacological Class
Digitalis glycoside
Manufacturer Description
Helps the heart pump better and controls irregular heart rhythms like atrial fibrillation.
Mechanism of Action
It works by increasing the force of the heart's contraction and slowing down the electrical signals between the top and bottom of the heart. This makes the heartbeat more efficient and regular.
Route of Administration
Oral
Onset Time
30 mins to 2 hours
Duration
36-48 hours
Contraindications
Ventricular tachycardia/fibrillation, Hypertrophic obstructive cardiomyopathy, Certain heart block conditions
Severe Adverse Events
Heart arrhythmias, Mental confusion, Gynaecomastia (long-term use), Severe vomiting (sign of toxicity)
Common Side Effects
Dizziness, Mild nausea
Uncommon Side Effects
Loss of appetite, Diarrhoea, Blurred or yellow vision, Rash
Drug Interactions
Amiodarone, Spironolactone, Verapamil, Certain antibiotics, Diuretics (due to potassium risk)
Pregnancy Safety Warnings
Can be used if clinically necessary under monitoring.
Age Restrictions
Suitable for all ages; doses are very precisely calculated.
Storage Guidelines
Store at room temperature in a dry place.
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Lanoxin FAQ

Can I travel internationally with Lanoxin tablets?

Yes, Lanoxin can be taken while traveling, but you should carry the original prescription label and a copy of the prescription. Keep the medication in its original container, and be aware that some countries may require documentation for controlled or prescription medicines.

Do the tablets have any distinctive markings?

In the UK, Lanoxin 0.25 mg tablets are typically round, white, and imprinted with “L-0.25”. Markings can vary slightly between manufacturers, so verify the imprint against the pharmacy label.

Will alcohol consumption affect Lanoxin?

Moderate alcohol intake does not directly alter digoxin levels, but excessive drinking can worsen heart failure and increase the risk of arrhythmias. Discuss your alcohol consumption with your clinician to ensure safe use.

Is Lanoxin detectable in drug-testing for athletes?

Yes, digoxin can be detected in blood and urine tests. While it is not a banned substance in most sports, athletes should disclose any prescribed medication to the relevant anti-doping authority.

How does Lanoxin differ from other heart-failure drugs like ACE inhibitors?

Lanoxin provides positive inotropic support and rate control, whereas ACE inhibitors reduce afterload and limit disease progression. They are often used together as part of a comprehensive heart-failure regimen, each addressing different pathophysiologic mechanisms.

What should I do if I miss a dose while on a weekend?

If you miss a dose and it is less than 12 hours until the next scheduled dose, simply skip the missed tablet and continue with your regular dosing time. Doubling the dose is not recommended.

Can I crush or split the 0.25 mg tablet?

Lanoxin tablets are not formulated for splitting or crushing, as this may lead to dose variability. If a lower dose is needed, your prescriber can provide a suitable formulation.

Are there any known drug-interaction warnings for over-the-counter cold remedies?

Some OTC cold medicines contain antihistamines or decongestants that can affect heart rhythm. While most do not directly alter digoxin levels, they may increase heart rate or cause palpitations. Consult your pharmacist before using such products.

Why is digoxin sometimes referred to as a “digitalis” drug?

Digoxin is derived from the foxglove plant (Digitalis purpurea), and all cardiac glycosides extracted from this family are collectively called digitalis drugs. The term reflects their botanical origin rather than a distinct pharmacologic class.

What is Lanoxin?

Lanoxin is a brand-name medication that contains the cardiac-glycoside digoxin as its sole active ingredient. It belongs to the Heart & Blood Pressure therapeutic class and is supplied as a pill (tablet) typically in a 0.25 mg strength. In the United Kingdom Lanoxin is a prescription-only medicine (POM) and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). The brand is marketed by a pharmaceutical company that manufactures digoxin-containing tablets for the treatment of certain heart conditions.

How Lanoxin Works in the Body

Digoxin exerts its therapeutic effect primarily by inhibiting the sodium-potassium ATP-ase pump in cardiac myocytes. This inhibition leads to an increase in intracellular sodium, which reduces the activity of the sodium-calcium exchanger. As a result, calcium accumulates inside the cells, enhancing the force of cardiac contraction (positive inotropy).

In addition to strengthening contraction, digoxin slows electrical conduction through the atrioventricular (AV) node, producing a negative chronotropic effect that helps control rapid heart rhythms such as atrial fibrillation.

  • Onset of action: 30 minutes to 2 hours after oral dosing.
  • Peak effect: Approximately 6 hours.
  • Duration: 24 hours, supporting once-daily dosing.
  • Bioavailability: About 60-80 % when taken as a tablet; food does not markedly alter absorption.
  • Metabolism and elimination: Digoxin is minimally metabolised and is excreted unchanged by the kidneys; renal function therefore strongly influences drug levels.

Conditions Treated by Lanoxin

Lanoxin is approved in the UK for the following indications:

  • Chronic heart failure (NYHA classes II-IV) when the patient is in sinus rhythm and other standard therapies are insufficient.
  • Atrial fibrillation or atrial flutter for rate control, particularly when β-blockers or calcium-channel blockers are not tolerated or are contraindicated.

The medication is generally prescribed for adult patients who have stable renal function and normal electrolyte balances. Adjustments are made for elderly patients, those with impaired kidney function, or patients with concomitant drugs that affect digoxin clearance.

Off-Label and Investigational Applications

Some clinicians have explored the use of digoxin for supraventricular tachycardias or for post-operative atrial fibrillation prophylaxis. Evidence from randomized trials is limited, and these uses are not approved by the MHRA.

Disclaimer: Off-label use of Lanoxin requires careful medical supervision, individualized risk assessment, and close monitoring of serum digoxin concentrations.

Who Should Not Use Lanoxin?

Absolute contraindications

  • Known hypersensitivity to digoxin or any cardiac glycoside.
  • Ventricular fibrillation, ventricular tachycardia, or any uncontrolled tachyarrhythmia.
  • Second- or third-degree AV block without a functioning pacemaker.
  • Acute myocardial infarction with pulmonary edema (unstable heart failure).

Relative contraindications and cautionary situations

  • Renal impairment (creatinine clearance < 50 mL/min) - dose reduction required.
  • Electrolyte disturbances (especially low potassium, low magnesium, or high calcium).
  • Thyroid disease (hyperthyroidism may increase digoxin toxicity).
  • Pregnancy - classified as category D; use only if benefits outweigh risks.
  • Breast-feeding - digoxin passes into milk; caution advised.
  • Elderly - increased susceptibility to toxicity; start with lower dose.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Nausea, vomiting, loss of appetite - usually transient.
  • Fatigue or weakness - may improve with dose adjustment.
  • Visual disturbances (blurry vision, yellow-green halos) - signal early toxicity.
  • Headache - typically mild.

Serious Adverse Events

  • Cardiac arrhythmias (e.g., premature ventricular beats, atrioventricular block).
  • Severe gastrointestinal upset leading to dehydration.
  • Life-threatening digoxin toxicity - requires immediate medical attention.

Drug Interactions

  • CYP3A4 inhibitors (e.g., amiodarone, clarithromycin, quinidine) increase digoxin levels.
  • P-glycoprotein inhibitors (e.g., verapamil, diltiazem) raise serum concentrations.
  • Diuretics (especially loop diuretics) may cause potassium loss, heightening toxicity risk.
  • Antithyroid drugs - may exacerbate digoxin’s effects on the heart.

Food and Lifestyle Interactions

  • High-fiber meals can modestly reduce absorption; take with water and maintain consistent timing.
  • Alcohol - occasional intake is acceptable, but excess can worsen heart failure.
  • Driving or operating machinery - most patients can remain active, but severe arrhythmia or dizziness warrants caution.

Patients should provide a complete medication list-including over-the-counter products and herbal supplements-to their healthcare provider before starting Lanoxin.

How to Take Lanoxin

  • Standard dosing: The usual adult dose is 0.25 mg once daily.
  • Initiation: Begin at the lowest dose, particularly in elderly patients, those with renal impairment, or those weighing less than 70 kg.
  • Adjustment: Dose may be lowered to 0.125 mg if serum digoxin concentrations exceed the therapeutic window (0.5-2.0 ng/mL) or if adverse effects appear.
  • Renal adjustment: For creatinine clearance < 50 mL/min, a reduced dose (often 0.125 mg) is recommended.
  • Administration: Swallow the tablet whole with a glass of water; it may be taken with or without food.
  • Missed dose: If a dose is missed and the next scheduled dose is more than 12 hours away, take the missed tablet. Do not double-dose.
  • Overdose: Symptoms may include nausea, vomiting, visual changes, and cardiac arrhythmias. Seek emergency care; treatment may involve activated charcoal and digoxin-specific antibody fragments (Digibind).
  • Discontinuation: Abrupt cessation is generally safe, but in patients with heart failure, the prescriber may taper the dose to monitor for rebound symptoms.

Monitoring and Follow-Up

  • Serum digoxin concentration: Check 6-8 hours after the first dose, then periodically (e.g., every 3 months) or after any dose change.
  • Renal function: Serum creatinine and estimated glomerular filtration rate (eGFR) at baseline and whenever renal status may have changed.
  • Electrolytes: Potassium, magnesium, and calcium levels should be measured, especially when using diuretics.
  • Electrocardiogram (ECG): Baseline ECG to assess AV conduction; repeat if symptoms of arrhythmia develop.
  • Clinical assessment: Evaluate heart failure signs (e.g., edema, dyspnea) at each clinic visit.

Storage and Handling

  • Store Lanoxin tablets at room temperature (15-25 °C), protected from excess moisture and light.
  • Keep the container tightly closed and out of reach of children.
  • Do not use the medication after the expiry date printed on the package.
  • Dispose of unused tablets according to local pharmacy take-back schemes or the instructions on the label.

Medication-Specific Glossary

Positive Inotropy
An increase in the force of heart muscle contraction, produced by digoxin’s effect on calcium handling.
Digitalis Toxicity
A potentially life-threatening condition caused by excess digoxin, characterised by gastrointestinal upset, visual changes, and cardiac arrhythmias.
AV Nodal Delay
Slowing of electrical conduction through the atrioventricular node, which helps control rapid heart rates in atrial fibrillation.
Serum Digoxin Concentration
The amount of digoxin measured in blood (ng/mL); therapeutic range is generally 0.5-2.0 ng/mL.
Renal Clearance
The process by which the kidneys eliminate digoxin; reduced clearance necessitates dose reduction.
Electrolyte Imbalance
Abnormal levels of potassium, magnesium, or calcium that can predispose patients to digoxin toxicity.

Medical Disclaimer

This article provides educational information about Lanoxin and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Lanoxin is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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