Buy Fluticasone + Salmeterol
Fluticasone + Salmeterol

42.78
Fluticasone + Salmeterol is a combination therapy used to manage asthma and chronic obstructive pulmonary disease. It combines a corticosteroid to reduce inflammation with a long-acting bronchodilator to keep the airways open for easier breathing.


Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Fluticasone, Salmeterol Xinafoate
Reference Brand
Seretide
Product Form
MDI (Evohaler), Dry Powder Inhaler (Accuhaler)
Regulatory Classification
Rx
Primary Category
Asthma control, COPD management
Product Category
Adrenergics in combination with corticosteroids, Inhaled bronchodilators
Pharmacological Class
Inhaled Corticosteroid (ICS), Long-Acting Beta-Agonist (LABA)
Manufacturer Description
A regular preventative inhaler used to manage long-term breathing conditions like asthma and COPD.
Mechanism of Action
This combined inhaler works in two ways: Fluticasone reduces inflammation and swelling in the airways, while Salmeterol relaxes the muscles in the airway walls to keep them open for a longer period, making breathing easier.
Route of Administration
Inhalation
Onset Time
30-60 minutes for bronchodilation
Duration
12 hours
Contraindications
Status asthmaticus, Acute asthma attacks, Severe milk protein allergy (for certain inhaler types)
Severe Adverse Events
Bronchospasm, Pneumonia in COPD patients, Glaucoma, Reduced bone density
Common Side Effects
Hoarseness, Throat irritation, Headache
Uncommon Side Effects
Oral thrush, Palpitations, Muscle cramps
Drug Interactions
Beta-blockers, Ritonavir, Ketoconazole
Pregnancy Safety Warnings
Discuss with a doctor; benefits usually outweigh risks for asthma control.
Age Restrictions
Children 4 years and older (strength dependent)
Storage Guidelines
Store in a cool dry place away from direct sunlight.
Related Products
Symbicort, Fostair, Advair

Fluticasone + Salmeterol FAQ

Can I use Fluticasone + Salmeterol during an asthma attack?

No. The inhaler is a maintenance therapy and does not act quickly enough to relieve acute bronchospasm. For sudden symptoms, a short-acting β2-agonist such as salbutamol should be used.

What should I do if I develop a sore throat after using the inhaler?

A sore throat can be an early sign of oral thrush. Rinse your mouth with water and spit it out after each inhalation. If symptoms persist, contact a healthcare professional for possible antifungal treatment.

Is it safe to travel abroad with my inhaler?

Yes, but keep the inhaler in its original packaging with the prescription label visible. Some countries require a doctor's note for inhaled medications; carry a copy of the prescription if you plan to travel long-term.

Do I need a spacer device with this inhaler?

A spacer is generally not required for dry-powder inhalers, but if you struggle with coordination, ask a pharmacist whether a spacer could improve drug delivery.

Can I use other inhaled steroids while on Fluticasone + Salmeterol?

Concurrent use of additional inhaled corticosteroids can increase the risk of systemic steroid side effects. Any change in therapy should be reviewed by a clinician.

How long does it take to feel the benefit after starting the inhaler?

Anti-inflammatory effects from fluticasone may take several days to weeks to reach full benefit, while the bronchodilator action of salmeterol begins within minutes. Most patients notice improved symptom control within 2-4 weeks.

Is the inhaler compatible with a dry-powder inhaler (DPI) for other medications?

Yes, you can use multiple DPIs, but remember to clean your mouth between different devices to avoid cross-contamination and to maintain optimal dosing.

What are the environmental considerations for disposing of the inhaler?

Do not puncture or incinerate the canister. Return used inhalers to a pharmacy’s medication-return program or follow local hazardous-waste guidelines.

Can pregnant women use this inhaler?

Fluticasone and salmeterol are classified as pregnancy category B in the UK, indicating no evidence of risk in animal studies and limited human data. A clinician should weigh the benefits of asthma control against any potential risks.

Why is my inhaler sometimes hard to press?

Propellant pressure can decrease as the dose counter approaches zero or if the device is stored in extreme temperatures. If resistance persists, replace the inhaler promptly.

Fluticasone + Salmeterol: Inhaler Overview

Fluticasone + Salmeterol is a prescription inhaler that combines two active ingredients: fluticasone propionate, an inhaled corticosteroid (ICS), and salmeterol xinafoate, a long-acting β2-adrenergic agonist (LABA). The device delivers either 250 µg/50 µg or 500 µg/50 µg of the two compounds per inhalation. In the United Kingdom the product is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) and is listed on the NHS prescribing formulary for long-term management of asthma and, in selected patients, chronic obstructive pulmonary disease (COPD). It is not intended for immediate relief of breathlessness.

How Fluticasone + Salmeterol Works in the Body

  • Fluticasone propionate binds to glucocorticoid receptors in airway epithelial cells, altering gene transcription to suppress the production of inflammatory cytokines, eosinophils, and other mediators that narrow the airways.
  • Salmeterol xinafoate activates β2-adrenergic receptors on bronchial smooth muscle, causing relaxation and bronchodilation that begins within 15 minutes and lasts up to 12 hours.
  • The combination provides both anti-inflammatory control (fluticasone) and sustained bronchodilation (salmeterol), reducing the frequency of asthma exacerbations and improving lung function.

Because the two agents act on different pathways, their effects are additive rather than overlapping, allowing lower doses of each component compared with using them separately.

Conditions Treated by Fluticasone + Salmeterol

  • Maintenance therapy for asthma in patients whose disease is not adequately controlled with a single-ingredient inhaled corticosteroid.
  • Maintenance therapy for COPD where a clinician decides that combined anti-inflammatory and bronchodilator action is appropriate, in line with NICE guideline NG115.

The inhaler is prescribed for adults and adolescents (≥12 years) who require regular, twice-daily treatment to maintain symptom control and prevent exacerbations. It is not a rescue inhaler for sudden breathlessness.

Patient Suitability and Contraindications

Who Should Use Fluticasone + Salmeterol?

  • Individuals with persistent asthma or COPD who need both anti-inflammatory and long-acting bronchodilator therapy.
  • Patients who can demonstrate correct inhaler technique and are able to adhere to twice-daily dosing.

Absolute Contraindications

  • Known hypersensitivity to fluticasone propionate, salmeterol xinafoate, or any excipient in the inhaler.
  • History of severe hypersensitivity reactions (e.g., anaphylaxis) to other inhaled corticosteroids or LABAs.

Relative Contraindications

  • Primary adrenal insufficiency or systemic steroid dependence (fluticasone may exacerbate adrenal suppression).
  • Unstable cardiac disease, arrhythmias, or hypertension (beta-agonist effects may increase heart rate and pulse).
  • Pregnancy (category B) and breastfeeding: benefits must outweigh any potential risks; a clinician should evaluate each case.
  • Children under 12 years: the inhaler is not licensed for this age group.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Oral thrush (candidiasis) - ~10 % of users.
  • Hoarseness or voice change.
  • Headache.
  • Mild tremor or palpitations.

Good oral hygiene-rinsing the mouth with water after each inhalation-reduces the risk of thrush and hoarseness.

Serious Adverse Events

  • Paradoxical bronchospasm (worsening wheeze shortly after inhalation).
  • Adrenal suppression with prolonged high-dose fluticasone use.
  • Increased risk of pneumonia in COPD patients receiving high-dose inhaled corticosteroids.
  • Cardiovascular events (tachyarrhythmia, angina) in patients with existing heart disease.

If any of these occur, the inhaler should be stopped and medical advice sought promptly.

Drug Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) can raise systemic fluticasone levels, potentially worsening steroid-related side effects.
  • Non-selective β-blockers (e.g., propranolol) may diminish the bronchodilator effect of salmeterol.
  • Other bronchodilators (short-acting β2-agonists, anticholinergics) can be used concurrently but may increase the risk of tachycardia.

Patients should provide a complete medication list-including over-the-counter products and herbal supplements-to their prescriber.

Food and Lifestyle Interactions

  • No significant food-drug interactions are known for this inhaler.
  • Alcohol does not interfere with efficacy, but excessive consumption may exacerbate underlying respiratory disease.
  • Operating heavy machinery or driving is generally safe, but patients experiencing tremor or palpitations should assess their own fitness for such activities.

How to Take Fluticasone + Salmeterol

  • Standard dosing: one inhalation (250 µg/50 µg or 500 µg/50 µg) twice daily, approximately 12 hours apart, regardless of meals.
  • Special populations:
  • Renal or hepatic impairment: no dose adjustment is required, but clinicians may monitor for systemic steroid effects.
  • Elderly: start with the lower strength (250 µg/50 µg) if disease control is mild; titrate based on response.
  • Inhaler technique:
  • Shake the inhaler (if a metered-dose device) and exhale fully before placing the mouthpiece in the mouth.
  • Press the canister once while inhaling slowly and deeply; hold breath for about 10 seconds, then exhale slowly.
  • Missed dose: take the missed inhalation as soon as remembered unless it is less than 6 hours before the next scheduled dose; do not double the dose.
  • Overdose: symptoms may include severe throat irritation, hoarseness, or systemic glucocorticoid effects (e.g., Cushingoid features). Seek urgent medical attention; treatment is supportive.
  • Discontinuation: abrupt cessation is generally safe, but clinicians may taper the inhaled corticosteroid component in patients on high doses to avoid adrenal insufficiency.

Monitoring and Follow-Up

  • Asthma control: Review using the Asthma Control Test (ACT) or a similar questionnaire at each visit.
  • Lung function: Spirometry (FEV₁) at baseline and periodically to assess response.
  • Inhaler technique: Check at every appointment; incorrect use reduces drug delivery by up to 50 %.
  • Oral health: Inspect for candidiasis; treat with antifungal mouthwash if needed.
  • Systemic effects: In patients on the higher 500 µg/50 µg dose for >3 months, consider morning serum cortisol testing to screen for adrenal suppression.

Storage and Handling

  • Keep the inhaler below 30 °C (86 °F) and protected from moisture and direct sunlight.
  • Store out of reach of children; many inhalers have a child-resistant cap.
  • Do not expose the device to temperatures below freezing, as propellant performance may be compromised.
  • Replace the inhaler after the expiration date printed on the packaging, even if doses remain.

Medication-Specific Glossary

Inhaled Corticosteroid (ICS)
A steroid medication delivered directly to the airways to reduce inflammation with minimal systemic absorption.
Long-acting β2-agonist (LABA)
A bronchodilator that stimulates β2-adrenergic receptors, producing prolonged airway smooth-muscle relaxation lasting 12 hours or more.
Paradoxical bronchospasm
An unexpected worsening of airway narrowing that occurs shortly after inhalation of a medication intended to open the airways.
Bronchospasm
Contraction of the smooth muscle surrounding the bronchi, leading to narrowed airways and difficulty breathing.

Medical Disclaimer

This article provides educational information about Fluticasone + Salmeterol and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Fluticasone + Salmeterol is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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