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Fenofibrate

1.28
Generic Fenofibrate is a fibrate medication used to treat high blood cholesterol and triglyceride levels. It works by increasing the natural breakdown of fats in the blood, which helps reduce the risk of pancreas issues and cardiovascular complications in adults with lipid disorders.


Ingredient
Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Fenofibrate
Reference Brand
Lipantil
Product Form
Tablet, Capsule
Regulatory Classification
Rx
Primary Category
Cholesterol Management
Product Category
Lipid-regulating drugs, Fibrates
Pharmacological Class
Peroxisome Proliferator Activated Receptor alpha Agonists
Manufacturer Description
A medication used alongside diet and exercise to lower high levels of fats and cholesterol in the blood.
Mechanism of Action
It works by activating a specific receptor in the body that increases the breakdown of lipids. This helps to lower 'bad' cholesterol and triglycerides while increasing 'good' cholesterol levels, improving the overall lipid profile in the blood.
Route of Administration
Oral
Onset Time
Several days
Duration
24 hours
Contraindications
Gallbladder disease, Severe kidney disease, Severe liver disease, Photoallergy to fibrates
Severe Adverse Events
Muscle pain or weakness, Jaundice, Pancreatitis, Blood clots
Common Side Effects
Abdominal pain, Nausea, Flatulence, Diarrhoea
Uncommon Side Effects
Skin rash, Headache, Altered liver function tests, Sensitivity to sunlight
Drug Interactions
Warfarin, Statins, Ciclosporin
Pregnancy Safety Warnings
Not recommended during pregnancy or breastfeeding.
Age Restrictions
Not recommended for children
Storage Guidelines
Store at room temperature in a dry place
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Fenofibrate FAQ

Can I travel with fenofibrate and go through airport security?

Yes. Fenofibrate tablets are permissible in hand luggage or checked baggage. Keep them in their original packaging with the prescription label visible to avoid delays at security checkpoints.

Does fenofibrate affect cholesterol testing for driving licence renewal?

The UK Driving and Vehicle Licensing Agency (DVLA) does not require cholesterol values for licence renewal. However, if you are under a medical review, provide accurate lipid results to your doctor.

What does a fenofibrate tablet look like?

Common generic fenofibrate tablets are white, round or oval, and may be imprint-coded with the strength (e.g., “160” or “200”). Inactive ingredients can include lactose, magnesium stearate, and microcrystalline cellulose.

Are there differences between fenofibrate products in the UK and other countries?

Formulation strength (160 mg vs 200 mg) and tablet size are generally similar, but excipients may vary. UK products must meet MHRA standards for quality and safety.

Can fenofibrate cause a positive drug test for athletes?

Fenofibrate is not a prohibited substance by the World Anti-Doping Agency (WADA). However, athletes should disclose all medications to their anti-doping authority to avoid inadvertent issues.

How was fenofibrate discovered?

Fenofibrate was first synthesized in the 1970s as part of the fibrate family, aiming to develop agents that could lower triglycerides by activating PPAR-α. It received UK market approval in the early 1990s for severe hypertriglyceridaemia.

Is fenofibrate cheaper than brand-name lipid-lowering drugs?

Generic fenofibrate is typically less expensive than patented statins or newer lipid therapies. Prices can vary between pharmacies, and the NHS provides it at standard prescription rates.

What should I do if I miss a dose while on a high-fat diet?

Take the missed tablet with your next main meal; the presence of dietary fat enhances absorption, so timing with a substantial meal is recommended.

Can I store fenofibrate in a bathroom cabinet?

It is best to keep fenofibrate in a cool, dry place away from humidity. A bathroom cabinet may become damp; storing the medication in a bedroom drawer or kitchen cupboard is preferable.

Do I need to fast before blood tests while taking fenofibrate?

For lipid panels, fasting for 9-12 hours is traditionally recommended, though non-fasting tests are increasingly accepted. Fenofibrate does not require a specific fasting period beyond the laboratory’s protocol.

Fenofibrate: Cholesterol-Lowering Pill Overview

Fenofibrate belongs to the fibrate class of medicines and is used to improve abnormal blood-lipid levels. It is available in the United Kingdom as a prescription-only pill, most commonly in 160 mg and 200 mg strengths. The drug works by modifying the way the body processes fats, helping to lower triglycerides and raise “good” HDL-cholesterol while modestly reducing LDL-cholesterol. Fenofibrate is marketed under various generic names; no specific brand name is required for this educational article.

How Fenofibrate Works in the Body

Fenofibrate activates a nuclear receptor called peroxisome proliferator-activated receptor-α (PPAR-α). By turning this receptor on, the drug stimulates enzymes that:

  • Increase the breakdown of triglyceride-rich particles (very-low-density lipoproteins, VLDL) in the liver and muscle.
  • Boost the production of high-density lipoprotein (HDL), which helps transport cholesterol away from arteries.
  • Reduce the synthesis of new triglycerides.

These actions together lower the amount of circulating triglycerides, modestly lower low-density lipoprotein (LDL) cholesterol, and raise HDL cholesterol. The therapeutic effect usually begins within a few days, reaches a steady level after 2-4 weeks, and persists as long as the medication is taken.

Conditions Treated by Fenofibrate

Fenofibrate is approved by the Medicines and Healthcare products Regulatory Agency (MHRA) for the following indications:

  • Severe hypertriglyceridaemia (triglyceride levels > 5 mmol/L) to reduce the risk of pancreatitis.
  • Mixed dyslipidaemia where triglycerides are elevated and HDL-cholesterol is low, especially when statins alone do not achieve target levels.
  • Familial hypercholesterolaemia as an adjunct to diet and other lipid-lowering therapies.

It is prescribed for adult patients (typically ≥ 18 years) who have documented lipid abnormalities that meet the above criteria.

Evidence-Based Off-Label Uses

Research studies have explored fenofibrate in several additional settings:

  • Type 2 diabetes: Adding fenofibrate to statin therapy can further lower triglycerides and modestly improve glycaemic control. This use is not approved by the MHRA and should only be considered under specialist supervision.
  • Cardiovascular risk reduction: Large trials (e.g., the FIELD and ACCORD studies) examined fenofibrate for preventing heart attacks and strokes. While some sub-groups showed benefit, the overall results did not lead to a new indication. Use for primary prevention remains off-label.

Disclaimer: Off-label use of fenofibrate requires careful medical assessment and monitoring. It should only be initiated by a qualified healthcare professional.

Who Should (and Should Not) Use Fenofibrate?

Ideal Candidates

  • Adults with markedly elevated triglycerides who are at risk of pancreatitis.
  • Patients whose HDL-cholesterol is low despite lifestyle measures and/or statin therapy.
  • Individuals with stable liver function and adequate renal clearance.

Absolute Contraindications

  • Known hypersensitivity to fenofibrate or any component of the tablet.
  • Active, severe liver disease (elevated transaminases > 3 × upper limit of normal).
  • End-stage renal disease (creatinine clearance < 30 mL/min).
  • Pregnancy or breastfeeding (fenofibrate is classified as contraindicated in pregnancy due to potential fetal harm).

Relative Contraindications & Cautions

  • Mild to moderate renal impairment (creatinine clearance 30-50 mL/min) - dose may need adjustment.
  • History of gallstones - fibrates can increase the risk of biliary sludge.
  • Concurrent use of statins, especially high-dose simvastatin, due to an increased risk of muscle toxicity.
  • Patients on anticoagulants (e.g., warfarin) - fenofibrate can enhance anticoagulant effect; INR should be monitored.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Gastrointestinal discomfort (abdominal pain, nausea, dyspepsia) - usually mild and transient.
  • Headache - often resolves with continued therapy.
  • Elevated liver enzymes - monitored with routine blood tests.
  • Muscle aches (myalgia) - most cases are benign, but they warrant assessment.

Serious Adverse Events

  • Rhabdomyolysis - rare but potentially life-threatening muscle breakdown, more likely when combined with high-dose statins.
  • Severe hepatic injury - indicated by jaundice, dark urine, or markedly raised transaminases.
  • Gallstone formation - fibrates can increase cholesterol saturation in bile.

Drug Interactions

  • Statins (especially simvastatin, lovastatin) - may increase the risk of myopathy; consider lower statin doses or alternative agents.
  • CYP2C9 inhibitors (e.g., fluconazole, amiodarone) - can raise fenofibrate plasma concentrations.
  • Warfarin - fenofibrate may potentiate anticoagulation; monitor INR closely.
  • Oral hypoglycaemic agents - fenofibrate can modestly reduce blood glucose; dose adjustments may be required.

Food and Lifestyle Interactions

  • Take with a main meal - high-fat meals improve fenofibrate absorption.
  • Alcohol - excessive intake can increase triglyceride levels and liver strain; moderation is advised.
  • Driving - fenofibrate does not impair alertness, but severe muscle pain or weakness could affect performance.

How to Take Fenofibrate

  • Standard dosing: One tablet of 160 mg taken once daily with the main meal. If lipid targets are not achieved and tolerability is good, the dose may be increased to 200 mg once daily.
  • Renal adjustment: For creatinine clearance 30-50 mL/min, the 160 mg dose is generally preferred; avoid 200 mg.
  • Swallow whole - do not crush or chew the pill, as this may affect drug release.
  • Missed dose: Take the missed tablet as soon as remembered on the same day; do not double the next dose.
  • Overdose: Symptoms may include nausea, vomiting, abdominal pain, and dizziness. Seek immediate medical attention; supportive care is the mainstay of treatment.
  • Discontinuation: No tapering is required, but inform your clinician before stopping, especially if you are also on a statin, to allow lipid levels to be re-checked.

Monitoring and Follow-Up

Regular monitoring helps ensure safety and effectiveness:

  • Liver function tests (ALT, AST, ALP, bilirubin) at baseline, then every 3-6 months.
  • Renal function (serum creatinine, eGFR) at baseline and periodically, especially in older adults.
  • Lipid profile after 4-6 weeks to assess response, then every 6-12 months.
  • Creatine kinase (CK) if muscle pain, weakness, or dark urine develops.

Promptly report any unexplained muscle symptoms, jaundice, or severe abdominal pain to a healthcare professional.

Storage and Handling

  • Keep tablets in the original blister pack until use.
  • Store at room temperature (below 30 °C) away from moisture and direct sunlight.
  • Do not use after the expiry date printed on the package.
  • Keep out of reach of children; use child-proof containers if available.

Medication-Specific Glossary

Fenofibrate
A synthetic fibrate that activates PPAR-α to lower triglycerides and raise HDL-cholesterol.
PPAR-α (Peroxisome proliferator-activated receptor-α)
A nuclear receptor that regulates genes involved in fatty-acid oxidation and lipid metabolism.
Triglyceride
A type of fat in the blood; high levels increase the risk of pancreatitis and cardiovascular disease.
Rhabdomyolysis
Rapid breakdown of skeletal muscle releasing myoglobin into the bloodstream, potentially causing kidney injury.
CYP2C9
An enzyme in the liver that metabolises many drugs; inhibitors can raise fenofibrate levels.

Medical Disclaimer

This article provides educational information about fenofibrate and is not a substitute for professional medical advice. Treatment decisions, including the use of fenofibrate for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Fenofibrate is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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