Buy Cutivate
Cutivate

29.75
Cutivate (Fluticasone) is a potent topical corticosteroid used to treat various inflammatory skin conditions, including eczema and psoriasis. It helps adults and children manage itching, redness, and swelling. By reducing local inflammation, this medication supports the skin's healing process and provides lasting relief from chronic irritation.


Ingredient
Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Fluticasone
Reference Brand
Cutivate
Manufacturer
GlaxoSmithKline
Product Form
Cream, Ointment
Regulatory Classification
Rx
Primary Category
Skin Treatment
Product Category
Corticosteroids, potent (group III)
Pharmacological Class
Topical corticosteroids
Clinical Indications
Manufacturer Description
A potent steroid cream used to treat various inflammatory skin conditions like eczema.
Mechanism of Action
It reduces inflammation, redness, and itching by inhibiting the release of chemicals that cause the immune response in the skin.
Route of Administration
Topical
Onset Time
1-2 days
Duration
Up to 12 hours
Contraindications
Untreated skin infections, Rosacea, Acne vulgaris, Skin itching without inflammation
Severe Adverse Events
Severe allergic reaction, Skin infection spread, Adrenal suppression (long-term use), Blurred vision
Common Side Effects
Stinging, Burning, Dryness
Uncommon Side Effects
Skin thinning, Stretch marks, Changes in skin colour, Excessive hair growth
Drug Interactions
Ritonavir, Itraconazole
Pregnancy Safety Warnings
Use sparingly and for short periods.
Age Restrictions
Suitable for infants over 3 months, children, and adults
Storage Guidelines
Store below 30°C; do not freeze.
Related Products
Betamethasone, Hydrocortisone, Mometasone

Cutivate FAQ

Can Cutivate be used on the face?

Cutivate is a high-potency topical steroid, and routine use on the face is generally discouraged because facial skin is thinner and more prone to atrophy. If a dermatologist prescribes it for facial lesions, the treatment period should be limited and closely monitored.

What should I do if I notice skin thinning while using Cutivate?

Skin thinning is a sign of local steroid excess. Discontinue the product and contact a healthcare professional promptly. They may recommend an alternative, lower-potency formulation or a tapering schedule.

Is it safe to use Cutivate while pregnant?

Topical fluticasone is classified as pregnancy category C in the UK. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus, and after discussing options with a prescriber.

How does Cutivate compare to other topical steroids like betamethasone?

Both are high-potency corticosteroids, but fluticasone has a slightly lower systemic bioavailability when applied topically, potentially reducing systemic side effects. Choice of agent depends on the specific condition, location, and physician preference.

Can I apply Cutivate after showering?

Yes. Applying the cream to clean, dry skin improves absorption. Wait a few minutes after washing to ensure the skin is fully dry before applying the medication.

What are the inactive ingredients in Cutivate?

The exact excipients are proprietary, but typical components of topical steroid tubes include emollients, preservatives, and stabilisers. If you have known allergies, ask your pharmacist for the full ingredient list.

Will using Cutivate affect a drug test for work or sport?

Topical fluticasone is not typically detected in standard urine drug screens. However, if large quantities are applied over extensive areas, trace systemic absorption could theoretically be measurable; discuss any concerns with your testing authority.

Is Cutivate covered by the NHS?

Prescription topical steroids such as Cutivate are usually reimbursed under the NHS when prescribed by a qualified clinician. Check with your local pharmacy for exact cost details.

How long does an opened tube of Cutivate remain stable?

When stored as directed, an opened tube is generally stable for up to 12 months. Always verify the expiry date printed on the packaging.

Can I travel with Cutivate in my hand luggage?

Yes. Cutivate in its original tube is permitted in hand luggage. Ensure the cap is tightly closed and the tube is placed in a clear, resealable bag to comply with airport security regulations.

What is Cutivate?

Cutivate is a topical skin-care medication that contains fluticasone as its active ingredient. It belongs to the class of synthetic glucocorticoids and is formulated in a tube available in 10 g and 20 g sizes. In the United Kingdom, Cutivate is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) and is generally prescribed for inflammatory skin conditions. The product is marketed as a prescription-only medicine (POM) and is not available over the counter.

How Cutivate Works in the Body

Fluticasone is a potent synthetic glucocorticoid that exerts anti-inflammatory and immunosuppressive effects by binding to intracellular glucocorticoid receptors. Once bound, the drug-receptor complex translocates to the cell nucleus and modulates gene transcription. This results in:

  • Reduced production of pro-inflammatory cytokines (e.g., interleukin-1, tumor necrosis factor-α)
  • Decreased migration of immune cells to the skin surface
  • Suppression of the arachidonic-acid pathway, lowering prostaglandin and leukotriene synthesis

These actions collectively diminish redness, swelling, itching, and other signs of skin inflammation. The topical formulation delivers the drug directly to the affected area, limiting systemic absorption and focusing the therapeutic effect where it is needed.

Conditions Treated by Cutivate

Cutivate is approved in the UK for the treatment of several dermatological conditions, including:

  • Atopic dermatitis (eczema) - to control flare-ups and relieve itching
  • Psoriasis vulgaris - for localized plaques where systemic therapy is unnecessary
  • Allergic contact dermatitis - to reduce inflammatory response after allergen exposure
  • Seborrhoeic dermatitis - for scalp and facial involvement when other treatments are insufficient

The medication is intended for short-term use on limited skin areas, as directed by a prescriber. For extensive disease, a healthcare professional may consider alternative systemic options.

Evidence-Based Off-Label Uses

Some clinicians have reported using topical fluticasone for other inflammatory dermatoses such as:

  • Lichen planus - limited case series suggest symptom relief, but evidence is not robust
  • Discoid lupus erythematosus - occasional use when standard therapies are contraindicated

These applications are off-label and are not approved by the MHRA. Off-label use requires medical supervision and an individualized risk-benefit assessment.

Who Should Not Use Cutivate?

Absolute Contraindications

  • Known hypersensitivity to fluticasone, other corticosteroids, or any excipients in the tube
  • Untreated fungal, bacterial, viral (e.g., herpes simplex), or parasitic skin infections in the area to be treated

Relative Contraindications

  • Skin that is thin, atrophic, or compromised (e.g., striae, bruises)
  • Use on the face, intertriginous zones, or over large surface areas without close monitoring
  • Pregnancy (category C) - only if the potential benefit outweighs risk; discuss with a prescriber
  • Breast-feeding - caution is advised; topical absorption is low but not negligible

Special Populations

  • Pediatric patients: Use is generally limited to children over 12 years; dosing should be guided by a pediatric dermatologist.
  • Elderly: Skin is more fragile; apply the thinnest possible layer and monitor for signs of atrophy.

If any of these conditions apply, a healthcare professional should evaluate suitability before initiating therapy.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Mild burning, stinging, or itching at the application site
  • Dryness or flaking of the skin
  • Slight erythema that usually resolves with continued use

These reactions are typically transient and lessen as the skin adapts.

Serious Adverse Events

  • Skin atrophy (thinning), striae, or telangiectasia with prolonged use or high-potency application
  • Hypothalamic-pituitary-adrenal (HPA) axis suppression - rare but possible if large areas are treated for weeks
  • Secondary infection of the treated skin (bacterial, fungal, or viral)

If any of these occur, discontinue the product and seek medical advice promptly.

Drug Interactions

Topical fluticasone can interact with:

  • Systemic glucocorticoids - additive systemic effects may increase the risk of adrenal suppression.
  • Other potent topical steroids - concurrent use can amplify local side-effects.
  • CYP3A4 inhibitors (e.g., ketoconazole cream) applied to the same area - may increase local fluticasone concentration.

Patients should disclose all current medications, including over-the-counter products and herbal preparations, to their prescriber.

Food and Lifestyle Interactions

  • No direct food interactions have been identified for topical fluticasone.
  • Avoid covering the treated area with occlusive dressings unless specifically instructed; occlusion can increase absorption and the risk of side effects.
  • Alcohol consumption does not affect topical absorption, but excessive drinking may impair wound healing.

How to Use Cutivate

  • Apply a thin layer to the affected skin once daily, or as directed by the prescriber.
  • Amount: For most adults, a fingertip unit (approximately 0.5 g) is sufficient for an area about the size of an adult hand. Adjust the quantity to match the size of the lesion, never exceeding the amount prescribed.
  • Timing: The medication can be applied in the morning or evening; consistency improves therapeutic outcomes.
  • Special Populations:
  • Renal or hepatic impairment: No dosage adjustment is required for topical use, but monitor for systemic effects if large areas are treated.
  • Elderly: Use the lowest effective potency and limit duration.
  • Children: Only use if prescribed; the amount should be reduced proportionally.

Missed Dose

If a dose is missed, apply it as soon as remembered unless it is close to the time of the next scheduled dose. Do not double the dose.

Overdose

Excessive application over large body surfaces may lead to systemic glucocorticoid effects such as Cushingoid features, hypertension, or hyperglycaemia. In case of suspected overdose, seek urgent medical attention; treatment is supportive and may include tapering the steroid.

Discontinuation

Do not stop abruptly after prolonged therapy on extensive areas. Gradual tapering-reducing frequency or potency over 1-2 weeks-helps prevent rebound inflammation and adrenal suppression.

Monitoring and Follow-Up

  • Short-term therapy (≤ 2 weeks): Routine clinical review is usually sufficient.
  • Long-term or extensive use: Periodic skin examinations are recommended to detect early signs of atrophy or secondary infection.
  • Systemic effects: If treatment exceeds 2 weeks on large areas, clinicians may order a morning serum cortisol test to assess HPA-axis function.

Patients should report persistent burning, unusual bruising, or signs of infection immediately.

Storage and Handling

  • Keep the tube at room temperature (15 °C - 30 °C).
  • Protect from direct sunlight and moisture.
  • Ensure the cap is tightly closed after each use.
  • Store out of reach of children and pets.
  • Do not use the product after the expiry date printed on the tube.

If the tube becomes damaged or the cream changes colour or odor, discard it according to local pharmacy disposal guidelines.

Medication-Specific Glossary

Glucocorticoid
A class of steroid hormones that modulate inflammation and immune responses by binding to intracellular receptors.
Potency
The relative strength of a topical corticosteroid; fluticasone is considered a high-potency agent for localized use.
HPA Axis
The hypothalamic-pituitary-adrenal axis, a hormonal system that regulates cortisol production; it can be suppressed by excessive topical steroid absorption.
Occlusion
The covering of a treated skin area with a dressing or plastic wrap, which can increase drug absorption and risk of side effects.

Medical Disclaimer

This article provides educational information about Cutivate and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Cutivate is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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