Buy Cleocin
Cleocin

2.04
Cleocin (clindamycin) is a lincosamide antibiotic used to treat severe infections caused by susceptible anaerobic bacteria. It is frequently employed for respiratory tract, skin, and soft tissue infections. The medication functions by disrupting bacterial protein production, effectively slowing or stopping the spread of infection in the body.


Ingredient
Category
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Clindamycin
Reference Brand
Dalacin C
Manufacturer
Pfizer Limited
Product Form
Capsule, Topical gel, Vaginal cream, Injection
Regulatory Classification
Rx
Primary Category
Antibiotic
Product Category
Lincosamides, Antibacterials for systemic use
Pharmacological Class
Lincosamide antibiotic
Manufacturer Description
An antibiotic effective against serious bacterial infections, often used for dental issues, skin conditions, and internal infections.
Mechanism of Action
Clindamycin works by inhibiting bacterial protein synthesis. It binds to the bacterial ribosome, preventing the assembly of proteins necessary for the bacteria to survive and grow. It is particularly effective against anaerobic bacteria and certain skin-related microbes.
Route of Administration
Oral
Onset Time
1-3 hours
Duration
6-8 hours
Contraindications
Hypersensitivity to clindamycin, History of pseudomembranous colitis
Severe Adverse Events
Clostridium difficile infection, Severe skin peeling, Jaundice, Reduced blood cell counts
Common Side Effects
Abdominal pain, Mild rash
Uncommon Side Effects
Vomiting, Nausea, Diarrhoea, Altered sense of taste
Drug Interactions
Erythromycin, Neuromuscular blocking agents
Pregnancy Safety Warnings
Considered safe if clearly needed; consult a doctor.
Age Restrictions
Can be used in children with dosage adjusted by weight
Storage Guidelines
Keep in a cool, dry place.
Related Products
Erythromycin, Metronidazole, Flucloxacillin

Cleocin FAQ

Can Cleocin be taken on an empty stomach?

Cleocin is best absorbed when taken with food or a full glass of water, which also helps reduce stomach upset. If you miss a meal, you may still take the tablet but expect a higher chance of nausea.

What should I do if I develop persistent diarrhoea while on Cleocin?

Persistent diarrhoea could signal C. difficile infection. Contact your healthcare provider promptly; they may request a stool test and consider alternative therapy.

Is there a generic version of Cleocin available in the UK?

Yes. The active ingredient clindamycin is marketed by several manufacturers as a generic tablet, typically labelled simply as “Clindamycin 150 mg” or “Clindamycin 300 mg”.

How does the appearance of Cleocin tablets differ from other clindamycin brands?

Cleocin tablets are round, biconvex, and film-coated. The 150 mg tablets are pink, while the 300 mg tablets are white with a blue imprint “CL150” or “CL300” respectively. Appearance may vary slightly between manufacturers.

Will Cleocin affect my results on a drug test for employment or sport?

Clindamycin is not a prohibited substance in standard workplace or athletic drug-screening panels. However, disclose any prescription medication to the testing authority if required.

Can I travel internationally with a supply of Cleocin?

Yes, provided you carry the medication in its original labelled container, include a copy of the prescription, and comply with the destination country’s import regulations for prescription drugs.

Is it safe to use Cleocin while breastfeeding?

Small amounts of clindamycin are secreted in breast milk. Many clinicians consider it compatible with breastfeeding if the infant is monitored for signs of diarrhoea. Discuss risks and benefits with your healthcare provider.

How does Cleocin compare to amoxicillin for dental infections?

Cleocin offers strong activity against anaerobic bacteria often implicated in dental abscesses, whereas amoxicillin targets a broader range of aerobic organisms. Choice depends on the likely bacterial profile and allergy status.

What are the inactive ingredients in Cleocin tablets?

Common excipients include lactose monohydrate, microcrystalline cellulose, and magnesium stearate. Patients with lactose intolerance should confirm the exact formulation with their pharmacist.

Does Cleocin require dose adjustment for elderly patients?

Older adults may have reduced renal or hepatic function. While no universal dose reduction is mandated, clinicians often start at the lower end of the dosing range (150 mg) and adjust based on tolerance and kidney function.

What is Cleocin?

Cleocin is a brand-name prescription medication that contains the antibiotic clindamycin as its sole active ingredient. It is supplied as oral pill tablets in 150 mg and 300 mg strengths. In the United Kingdom, Cleocin is classified as a prescription-only medicine (POM) and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). The drug is used to treat a range of bacterial infections, particularly those caused by anaerobic organisms and certain Gram-positive bacteria.

How Cleocin Works in the Body

Clindamycin belongs to the lincosamide class of antibiotics. It exerts its antibacterial effect by binding to the 50 S subunit of bacterial ribosomes, thereby blocking the translocation step of protein synthesis. This inhibition prevents bacteria from producing essential proteins, leading to bacteriostatic activity at usual clinical doses and bactericidal activity against susceptible strains at higher concentrations. Because the drug is absorbed well from the gastrointestinal tract, therapeutic concentrations are achieved rapidly, with peak plasma levels typically occurring 1-2 hours after an oral dose. The half-life ranges from 2 to 3 hours, allowing dosing every 6 to 8 hours for most infections.

Conditions Treated with Cleocin

Cleocin is approved in the UK for the treatment of the following infections, when caused by susceptible bacteria:

  • Skin and soft-tissue infections (e.g., cellulitis, abscesses) where anaerobic or mixed flora are suspected
  • Bone and joint infections such as osteomyelitis, particularly when caused by Staphylococcus aureus or anaerobes
  • Anaerobic respiratory infections, including lung abscesses and empyema
  • Intra-abdominal infections (e.g., peritonitis, pelvic inflammatory disease) where anaerobes are implicated
  • Severe bacterial vaginosis unresponsive to first-line therapy
  • Sepsis caused by susceptible Gram-positive or anaerobic organisms, when alternative agents are unsuitable

The prescribing clinician will confirm that the infecting organism is likely to be sensitive to clindamycin, often guided by culture results or local resistance patterns.

Evidence-Based Off-Label Uses

Some clinical reports have explored off-label oral clindamycin for:

  • Helicobacter pylori eradication as part of combination therapy in patients intolerant of first-line agents.
  • Acne vulgaris (oral use) when topical therapies have failed, though the topical formulation is more common.

These uses are not approved by the MHRA for the oral formulation. Off-label treatment should only be undertaken after a thorough risk-benefit assessment by a qualified healthcare professional.

Who Should (Not) Use Cleocin?

Ideal Candidates

  • Adults with confirmed or strongly suspected infections caused by clindamycin-susceptible bacteria.
  • Patients without a history of severe C. difficile infection or known hypersensitivity to lincosamides.

Absolute Contra-indications

  • Documented hypersensitivity to clindamycin, lincomycin, or any lincosamide.
  • History of C. difficile-associated colitis (severe, recurrent).

Relative Contra-indications

  • Pregnancy - classified as Category B (no evidence of harm in animal studies; limited human data).
  • Lactation - clindamycin passes into breast milk in small amounts; benefits and risks should be weighed.
  • Renal impairment - dose reduction may be required when creatinine clearance <30 mL/min.
  • Hepatic dysfunction - caution in severe liver disease (Child-Pugh C) as metabolism is hepatic.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Gastrointestinal upset - nausea, abdominal pain, and a metallic taste.
  • Diarrhoea - often mild; may precede more serious colitis.
  • Skin reactions - rash or mild itching.

Serious Adverse Events

  • Clostridioides difficile-associated colitis - characterised by watery diarrhoea, abdominal tenderness, and fever; requires immediate medical attention.
  • Severe allergic reactions - urticaria, angioedema, or anaphylaxis (rare).
  • Liver enzyme elevations - reported infrequently; monitor if therapy exceeds 2 weeks.

Drug Interactions

  • Warfarin - clindamycin may potentiate anticoagulant effects, increasing INR; regular monitoring is advised.
  • Erythromycin and other macrolides - concurrent use can raise the risk of C. difficile colitis.
  • Neuromuscular blocking agents (e.g., rocuronium) - clindamycin may enhance blockade, relevant for patients undergoing surgery.
  • CYP3A4 substrates - clindamycin is a weak inhibitor; dose adjustments of sensitive drugs may be considered.

Food and Lifestyle Interactions

  • Take Cleocin with food or a full glass of water to minimise gastrointestinal discomfort.
  • No known interaction with moderate alcohol consumption, but excessive alcohol may worsen stomach irritation.
  • No specific restrictions on driving; however, if dizziness occurs, avoid operating machinery.

How to Take Cleocin

  • Standard adult dosing: 150 mg to 300 mg taken every 6 hours (four times daily). The exact dose depends on infection severity and site.
  • Maximum daily dose: 2.7 g (i.e., 9 tablets of 300 mg) for severe infections, administered under close supervision.
  • Renal adjustment: For creatinine clearance <30 mL/min, extend the dosing interval to every 8 hours or reduce dose to 150 mg.
  • Hepatic adjustment: In moderate hepatic impairment, use the lower end of the dosing range; avoid high-dose regimens in severe hepatic disease.
  • Administration: Swallow tablets whole; do not crush or chew unless specifically advised.
  • Missed dose: Take the missed tablet as soon as remembered unless the next scheduled dose is within 2 hours; do not double-dose.
  • Overdose: Symptoms may include severe diarrhoea, vomiting, and abdominal cramps. Seek urgent medical care; activated charcoal can be considered if presentation is early.
  • Discontinuation: For prolonged therapy, tapering is not required, but abrupt cessation may allow infection recurrence if not fully resolved.

Monitoring and Follow-Up

  • Clinical review should occur within 48-72 hours of initiating therapy to assess response and adverse effects.
  • Laboratory monitoring: baseline and periodic liver function tests for patients on therapy longer than 2 weeks; renal function tests for those with known kidney disease.
  • Signs to report: persistent diarrhoea, abdominal pain, bloody stool, or any severe rash. Prompt evaluation can prevent complications such as C. difficile colitis.

Storage and Handling

  • Store tablets at room temperature (≤25 °C), protected from excess moisture and light.
  • Keep the container tightly closed and out of reach of children.
  • Do not use tablets past the expiry date printed on the packaging.
  • For disposal, follow local pharmacy take-back schemes or the NHS disposal guidelines for unused medicines.

Medication-Specific Glossary

Clostridioides difficile infection
A potentially severe colitis caused by overgrowth of C. difficile bacteria, often precipitated by broad-spectrum antibiotics that disrupt normal gut flora.
Anaerobic bacteria
Microorganisms that thrive in environments lacking oxygen; many cause deep-tissue infections and are a primary target of clindamycin.
Protein synthesis inhibition
The process by which clindamycin blocks bacterial ribosomal function, preventing the formation of essential proteins needed for bacterial growth.
CYP3A4
A liver enzyme that metabolises many drugs; clindamycin can modestly inhibit this pathway, influencing the plasma levels of co-administered CYP3A4 substrates.
Black-box warning
A regulatory label highlighting a serious or life-threatening risk; in the UK, clindamycin’s most critical warning relates to the risk of C. difficile colitis.

Medical Disclaimer

This article provides educational information about Cleocin and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Cleocin is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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