Buy Cabergoline
Cabergoline

6.37
Generic Cabergoline is a dopamine agonist used primarily to treat medical conditions associated with high levels of the hormone prolactin. This includes the management of prolactin-secreting tumors and irregular menstrual cycles. By inhibiting prolactin secretion from the pituitary gland, Cabergoline helps restore hormonal balance and improves reproductive health symptoms.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Cabergoline
Reference Brand
Dostinex
Manufacturer
Pfizer Ltd
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Hormone Regulation
Product Category
Prolactin inhibitors, Dopamine agonists
Pharmacological Class
Ergot derivatives
Manufacturer Description
Used to treat conditions caused by high levels of the hormone prolactin or to manage symptoms of Parkinson’s.
Mechanism of Action
It works by mimicking the action of dopamine in the brain, which suppresses the production of prolactin from the pituitary gland. Prolactin is the hormone responsible for milk production and certain reproductive issues.
Route of Administration
Oral
Onset Time
2-5 hours
Duration
7-28 days (long-acting)
Contraindications
History of valvular heart disease, History of pulmonary or cardiac fibrosis, Preeclampsia or eclampsia, Uncontrolled hypertension
Severe Adverse Events
Heart valve problems, Shortness of breath, Persistent cough, Impulse control disorders
Common Side Effects
Nausea, Headache, Dizziness, Constipation
Uncommon Side Effects
Low blood pressure, Breast pain, Hot flushes, Heartburn
Drug Interactions
Antipsychotics, Metoclopramide, Erythromycin, Ergot alkaloids
Pregnancy Safety Warnings
Discontinue once pregnancy is confirmed unless required.
Age Restrictions
Not recommended for children under 16
Storage Guidelines
Store at room temperature; keep the container tightly closed.
Related Products
Bromocriptine, Quinagolide

Cabergoline FAQ

Can I travel internationally with cabergoline tablets?

Yes, cabergoline can be carried in your personal medication supply when travelling abroad. It is advisable to keep the original prescription label, carry a copy of the prescribing doctor’s note, and declare the medication at customs if required by the destination country’s regulations.

Will cabergoline affect my results on a drug test for work or sport?

Cabergoline is not a controlled substance and does not appear on standard employment or sports drug-testing panels. However, some specialized tests may detect ergot derivatives; informing the testing authority beforehand can prevent misunderstandings.

What does the imprint on the cabergoline pill look like?

In the UK, the 0.25 mg tablet typically bears the imprint “C 0.25” and the 0.5 mg tablet “C 0.5”. Imprints may vary by manufacturer, so compare with the packaging or pharmacy label.

Are there any differences between cabergoline sold in the UK and other countries?

The active ingredient and dosage strengths are consistent worldwide, but packaging, excipients, and regulatory approvals can differ. In the UK, cabergoline is prescribed under MHRA oversight, whereas other regions may have additional brand-specific formulations.

How long does it take for menstrual cycles to normalise after starting cabergoline?

Most women experience a return to regular ovulatory cycles within 4-8 weeks of achieving target prolactin levels, though individual responses vary. Ongoing monitoring of hormone levels helps guide therapy adjustments.

Is cabergoline safe for women planning a pregnancy?

Cabergoline is generally discontinued once pregnancy is confirmed because prolactin levels naturally rise to support lactation. Its use before conception is considered safe under specialist supervision, provided prolactin is normalised and pregnancy planning is discussed with a clinician.

What should I do if I experience dizziness after taking cabergoline?

Rise slowly from sitting or lying positions to minimise orthostatic hypotension. If dizziness persists, inform your healthcare provider, who may adjust the dosing schedule or evaluate blood pressure.

Can cabergoline be taken with birth control pills?

Yes, there are no known pharmacokinetic interactions between cabergoline and combined oral contraceptives. However, both medications can influence hormonal balance, so routine follow-up is recommended.

Why is cabergoline more expensive than some other prolactin-lowering agents?

Cabergoline’s longer half-life allows less frequent dosing, which can reduce overall treatment burden. Patent history, manufacturing processes, and market exclusivity can also influence price. In the UK, the NHS may subsidise the cost for eligible patients.

Is there a risk of developing tolerance to cabergoline over time?

Tolerance to the prolactin-lowering effect is uncommon. However, dose adjustments may be needed if prolactin levels rise again, indicating disease progression rather than drug tolerance.

Cabergoline: Generic Medication Overview

Cabergoline is a dopamine-agonist medication used primarily in women’s health as a hormone-therapy agent. It belongs to the class of ergot-derived dopamine receptor agonists and is available as oral pills in strengths of 0.25 mg and 0.5 mg. In the United Kingdom, cabergoline is a prescription-only medicine (POM) and is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA). It is most commonly prescribed to treat hyperprolactinaemia - a condition in which excess prolactin disrupts the menstrual cycle, fertility, and lactation.

How Cabergoline Works in the Body

Cabergoline stimulates dopamine D₂ receptors in the pituitary gland. Dopamine normally inhibits prolactin secretion; by mimicking dopamine, cabergoline reduces the amount of prolactin released into the bloodstream. The drug has a long half-life (approximately 65 hours), allowing for twice-weekly dosing rather than daily administration. Lower prolactin levels restore normal gonadal hormone balance, leading to the resolution of menstrual disturbances, galactorrhoea, and infertility associated with hyperprolactinaemia.

Conditions Treated by Cabergoline

  • Hyperprolactinaemia (both idiopathic and secondary to pituitary adenomas) - the primary approved indication in the UK.
  • Prolactin-secreting pituitary tumours (microadenomas) - cabergoline can shrink tumour size while normalising prolactin levels.

These uses are sanctioned by the MHRA based on clinical trial data demonstrating effective prolactin reduction and symptom relief. Cabergoline is not authorised for routine use in men’s hormone disorders or for Parkinson’s disease in the UK, although it may be prescribed off-label for those conditions under specialist supervision.

Evidence-Based Off-Label Uses

Cabergoline has been investigated for several off-label applications:

  • Parkinson’s disease - small studies suggest dopaminergic benefits, but the drug is not approved for this indication in the UK and carries a different risk profile.
  • Reduction of breast milk production in postpartum women - limited data indicate effectiveness, yet regulatory approval is lacking.

Off-label use requires medical supervision and individual risk assessment.

Who Should (Not) Use Cabergoline?

Ideal Patient Profile

  • Adults diagnosed with hyperprolactinaemia or a prolactin-secreting microadenoma.
  • Patients without uncontrolled hypertension or significant cardiac valvular disease.

Absolute Contraindications

  • Known hypersensitivity to cabergoline or any ergot derivative.
  • Uncontrolled hypertension (systolic > 160 mmHg or diastolic > 100 mmHg).
  • Existing moderate-to-severe valvular heart disease.
  • Pregnancy, unless the potential benefit justifies the risk (category B in the UK).

Relative Contraindications

  • Severe hepatic impairment.
  • History of psychiatric disorders (e.g., psychosis, severe depression).
  • Concomitant use of other ergot-derived medicines.
  • Elderly patients may require cautious titration due to increased sensitivity to hypotension.

Safety Profile and Interactions

Common Side Effects

  • Nausea and/or vomiting.
  • Headache.
  • Dizziness, especially when standing up quickly (orthostatic hypotension).
  • Fatigue or feeling “off”.
  • Constipation or abdominal discomfort.

These effects are generally mild and often improve as the body adapts to the medication.

Serious Adverse Events

  • Valvular heart disease - fibrotic changes in heart valves have been reported with long-term high-dose therapy; regular echocardiograms are advised.
  • Pulmonary fibrosis - rare but serious; monitor respiratory symptoms.
  • Impulse control disorders (e.g., compulsive gambling, eating) - may arise due to dopaminergic stimulation.
  • Psychosis or severe depression - patients with a history of psychiatric illness should be monitored closely.

If any of the above occur, seek immediate medical attention.

Drug Interactions

  • Antihypertensives - cabergoline can enhance blood-pressure-lowering effects; dose adjustments may be needed.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) - may increase cabergoline plasma concentrations; monitor for toxicity.
  • CYP3A4 inducers (e.g., carbamazepine, rifampicin) - may reduce effectiveness.
  • Serotonergic agents (e.g., SSRIs, MAO inhibitors) - theoretical risk of serotonin syndrome; use with caution.

Patients should disclose all current medications, including over-the-counter drugs and herbal supplements.

Food and Lifestyle Interactions

  • Cabergoline can be taken with or without food; however, a light snack may reduce nausea.
  • Alcohol may exacerbate dizziness and should be consumed cautiously.
  • No known impact on driving ability when the dose is well tolerated; avoid operating heavy machinery if experiencing dizziness.

How to Take Cabergoline

  • Standard dosing:
  • Initial: 0.25 mg taken orally twice weekly (e.g., Monday and Thursday).
  • Maintenance: Dose may be increased to 0.5 mg twice weekly based on prolactin levels and clinical response.
  • Administration tips:
  • Swallow the pill whole with a glass of water.
  • Do not crush or chew the tablet.
  • Take at the same times each week to maintain stable blood levels.
  • Missed dose:
  • If a dose is missed and the next scheduled dose is more than 24 hours away, take the missed dose as soon as remembered. Do not double-dose.
  • Overdose:
  • Symptoms may include severe nausea, vomiting, profound hypotension, and fainting. Seek emergency medical care; supportive measures are the mainstay of treatment.
  • Discontinuation:
  • Abrupt cessation is generally well tolerated, but prolonged therapy should be reviewed regularly. No tapering is required for the low weekly doses used in hyperprolactinaemia, though clinicians may adjust the schedule if side effects arise.

Monitoring and Follow-Up

  • Prolactin levels: Measured 4-6 weeks after starting therapy, then every 6-12 months once stable.
  • Blood pressure: Check at each visit, especially during dose escalation.
  • Cardiac monitoring: Baseline echocardiogram before initiating therapy, then annually if the patient continues long-term treatment or if the dose exceeds 0.5 mg per week.
  • Liver function tests: Consider baseline testing in patients with known hepatic disease.

Regular clinical review ensures that the therapeutic benefit outweighs any emerging risks.

Storage and Handling

  • Store tablets in the original container at a temperature not exceeding 30 °C.
  • Keep the medication away from moisture and direct sunlight.
  • Keep out of reach of children; use child-proof containers.
  • Do not use tablets after the expiry date printed on the pack.

If a dose is omitted for an extended period, discard any remaining tablets and obtain a new prescription.

Medication-Specific Glossary

Dopamine agonist
A drug that binds to dopamine receptors and mimics dopamine’s inhibitory effect on prolactin secretion.
Hyperprolactinaemia
An endocrine disorder characterised by excessive circulating prolactin, leading to menstrual disturbances, galactorrhoea, and fertility problems.
Echocardiogram
An ultrasound examination of the heart used to assess valve structure and function, essential for monitoring cabergoline-related valvulopathy.
Impulse control disorder
A psychiatric condition where the individual struggles to resist urges that may be harmful, such as compulsive gambling; can be triggered by dopaminergic therapy.
Valvular heart disease
Fibrotic changes in heart valves that can impair their function; a rare but serious adverse effect of long-term ergot-derived dopamine agonists.

Medical Disclaimer

This article provides educational information about cabergoline and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Cabergoline is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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