Buy Azelastine
Azelastine

27.54
Generic Azelastine is an antihistamine used to relieve nasal symptoms such as sneezing, itching, and congestion associated with seasonal allergies. It works by blocking histamine receptors in the nasal passages to reduce the inflammatory response. This targeted Azelastine delivery helps manage hay fever and vasomotor rhinitis efficiently.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Azelastine
Reference Brand
Rhinolast
Manufacturer
Mylan
Product Form
Nasal spray, Eye drops
Regulatory Classification
Rx
Primary Category
Allergy Relief
Product Category
Antihistamines, Second-generation antihistamines
Pharmacological Class
Phthalazinone derivatives
Manufacturer Description
An antihistamine used as a spray or drops to treat hay fever and allergy symptoms in the eyes and nose.
Mechanism of Action
Azelastine blocks the action of histamine, a natural substance in the body that causes allergic symptoms. By applying it directly to the nose or eyes, it reduces inflammation, itching, and congestion quickly.
Route of Administration
Topical
Onset Time
15-30 minutes
Duration
12 hours
Contraindications
Hypersensitivity to azelastine
Severe Adverse Events
Severe allergic reaction, Shortness of breath, Swelling of the face or throat
Common Side Effects
Bitter taste in mouth, Nasal irritation, Sneezing
Uncommon Side Effects
Drowsiness, Headache, Dry eyes, Cough
Drug Interactions
Alcohol, Cimetidine, Other sedating medications
Pregnancy Safety Warnings
Consult a doctor before use.
Age Restrictions
Children 6 years and over for nasal spray
Storage Guidelines
Store upright at room temperature. Do not refrigerate.
Related Products
Beclometasone, Olopatadine, Cetirizine

Azelastine FAQ

What is the difference between azelastine nasal spray and oral antihistamines?

Azelastine is applied directly to the nasal mucosa, providing rapid local relief with minimal systemic absorption. Oral antihistamines work throughout the body and may cause drowsiness, especially first-generation agents.

Can I use azelastine if I have a deviated septum?

Yes, azelastine can be used with a deviated septum, but avoid spraying directly onto the septum to reduce irritation. If severe pain or bleeding occurs, contact a clinician.

How long does a 10 ml bottle of azelastine typically last?

With the recommended dosing of one spray per nostril twice daily, a 10 ml bottle generally lasts about four weeks.

Is a prescription required for azelastine in the UK?

Yes, azelastine nasal spray is a prescription-only medicine (POM) regulated by the MHRA.

Can azelastine be used alongside a nasal steroid spray?

It can be used in combination, but they should be administered at different times (e.g., one in the morning, the other in the evening) to minimise local irritation.

Will azelastine affect my sense of smell?

Some users report temporary reduction in smell shortly after dosing, which usually resolves after continued use or when the medication is stopped.

Is azelastine safe for my teenage child?

Azelastine is approved for children aged 6 years and older. For teenagers, the same dosing regimen as adults is recommended unless a clinician advises otherwise.

Can I travel internationally with my azelastine sprayer?

Yes, but keep the bottle in its original packaging, carry it in hand luggage, and be prepared to show the prescription if asked at security.

Do I need to avoid certain foods while using azelastine?

No specific dietary restrictions are known for azelastine. Maintaining a balanced diet is advisable for overall allergy management.

What should I do if I experience a bitter taste after using the spray?

The bitter taste is a common, mild side effect. Avoid swallowing the spray solution and allow it to spread across the nasal mucosa. If the taste persists or is bothersome, discuss alternative formulations with your healthcare provider.

Azelastine: Generic Medication Overview

This article covers Azelastine, available as a generic medication and marketed under brand names such as Astepro and Astelin. Azelastine is classified as an allergy-relief (antihistamine) agent and is supplied as a 10 ml intranasal sprayer for the treatment of allergic rhinitis and related nasal symptoms. In the United Kingdom it is a prescription-only medicine (POM) regulated by the Medicines and Healthcare products Regulatory Agency (MHRA).

How Azelastine Works in the Body

Azelastine is a second-generation antihistamine that blocks the H₁ histamine receptors located on nasal mucosal cells. By preventing histamine from binding to these receptors, azelastine reduces the inflammation, itching, sneezing, and runny nose that occur during an allergic response.

  • Onset of action: Most users notice relief within 15 minutes of the first spray.
  • Duration: The therapeutic effect lasts for about 8-12 hours, supporting twice-daily dosing.
  • Absorption: Only a small fraction of the dose is absorbed systemically; the majority remains localized in the nasal passages, limiting systemic side effects.

Conditions Treated by Azelastine

  • Seasonal allergic rhinitis (hay fever)
  • Perennial allergic rhinitis (year-round pollen or dust-mite allergy)

These indications are approved by the MHRA for use in adults and children aged 6 years and older. Azelastine relieves nasal congestion, sneezing, itching, and rhinorrhoea associated with these conditions.

Who Should (and Should Not) Use Azelastine?

Ideal Patient Profile

  • Adults and children ≥ 6 years with a physician-diagnosed allergic rhinitis
  • Individuals seeking a non-sedating nasal antihistamine

Absolute Contraindications

  • Known hypersensitivity to azelastine or any other component of the formulation

Relative Contraindications & Cautions

  • Pregnancy & lactation: Use only if clearly needed; limited data suggest it is relatively safe but should be prescribed after risk-benefit assessment.
  • Severe hepatic impairment: Because azelastine is metabolised in the liver, dose adjustment may be required.
  • Concurrent use of other intranasal medications: May increase the risk of local irritation; separate administration by at least 5 minutes is advisable.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Nasal irritation or burning - usually mild and transient.
  • Unpleasant taste (bitter or metallic) - often reported shortly after dosing.
  • Mild headache - occurs in a small proportion of users.

Serious Adverse Events

  • Severe allergic reactions (e.g., angio-edema, anaphylaxis) - rare; seek immediate medical attention if swelling of the face, lips, or throat occurs.
  • Persistent nasal bleeding - uncommon; discontinue use and consult a clinician if it continues.

Drug Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): May modestly increase systemic azelastine levels, though clinical relevance is low because systemic exposure is minimal.
  • Other antihistamines or nasal decongestants: Additive effects on nasal dryness or irritation may occur; coordinate with a healthcare professional.

Food and Lifestyle Interactions

  • Alcohol: No direct interaction, but excessive alcohol can heighten nasal irritation.
  • Driving or operating machinery: Azelastine is non-sedating; it does not impair psychomotor performance.

Patients should always inform their healthcare provider of all medicines, supplements, and herbal products they are taking.

How to Take Azelastine

  • Standard regimen: One spray (approximately 0.05 ml) into each nostril twice daily (morning and evening).
  • Maximum dose: Do not exceed two sprays per nostril per day, as this equals the total amount contained in a 10 ml bottle after a typical 4-week course.
  • Administration tips:
  • Gently blow the nose before use.
  • Hold the bottle upright, insert the tip into one nostril, close the opposite nostril with a finger, and press the actuator once.
  • Repeat for the other side.
  • Avoid spraying directly onto the nasal septum to reduce irritation.
  • Missed dose: If a dose is missed, take it as soon as remembered unless it is near the time of the next scheduled dose; do not double-dose.
  • Overdose: Excessive nasal application may cause heightened irritation, bitter taste, or systemic effects such as drowsiness. Seek medical advice if large amounts are unintentionally administered.
  • Discontinuation: Azelastine may be stopped without tapering. If symptoms recur, advise the prescriber.

Monitoring and Follow-Up

Routine laboratory monitoring is not required for azelastine. However, patients should schedule a follow-up visit after 2-4 weeks of therapy to assess symptom control and any local adverse effects. Persistent nosebleeds, severe irritation, or lack of improvement warrant medical review.

Storage and Handling

  • Store the 10 ml sprayer at room temperature (15-25 °C), away from direct sunlight and moisture.
  • Keep the bottle tightly closed when not in use.
  • Do not freeze the solution.
  • Discard any remaining product after the expiry date printed on the label, even if some volume remains.
  • Keep out of reach of children; the sprayer is child-resistant but should be stored securely.

Medication-Specific Glossary

Antihistamine
A drug that blocks histamine H₁ receptors, preventing the typical allergic symptoms of itching, swelling, and mucus production.
Mast cell
An immune cell that releases histamine and other mediators during an allergic reaction, contributing to inflammation of the nasal lining.
Intranasal
Administration of a medication directly into the nasal cavities, allowing rapid local action and reduced systemic exposure.
Bioavailability (intranasal)
The proportion of the administered dose that reaches the systemic circulation; for azelastine nasal spray, this is low, limiting systemic side effects.

Medical Disclaimer

This article provides educational information about Azelastine and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Azelastine is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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