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Assurans

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Assurans (sildenafil) is a phosphodiesterase type 5 (PDE5) inhibitor used to manage erectile dysfunction and pulmonary arterial hypertension. It promotes blood vessel relaxation, allowing for increased blood flow to specific areas of the body. Assurans helps individuals achieve and maintain the physical response necessary for sexual activity.


Ingredient
Availability
In Stock
Delivery Time
Airmail (14-21 days) | EMS trackable (5-9 days)
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Product Sheet

Active Ingredient(s)
Sildenafil
Reference Brand
Revatio
Manufacturer
Cipla
Product Form
Tablet
Regulatory Classification
Rx
Primary Category
Pulmonary Hypertension
Product Category
Antihypertensives, Pulmonary arterial hypertension agents
Pharmacological Class
PDE5 Inhibitor
Manufacturer Description
A medication specifically used to treat high blood pressure in the vessels supplying the lungs.
Mechanism of Action
Assurans relaxes the blood vessels in the lungs, lowering the blood pressure in the pulmonary arteries. This improves the heart's ability to pump blood through the lungs and increases exercise capacity in patients.
Route of Administration
Oral
Onset Time
30-60 minutes
Duration
6-8 hours
Contraindications
Nitrate medication use, Riociguat use, Severe hepatic impairment
Severe Adverse Events
Visual disturbances, Sudden hearing loss, Shortness of breath, Chest pain
Common Side Effects
Flushing, Headache, Indigestion
Uncommon Side Effects
Nasal congestion, Back pain, Diarrhoea
Drug Interactions
Nitrates, Beta-blockers, Ritonavir, Bosentan
Pregnancy Safety Warnings
Consult a doctor; generally used if clinically necessary.
Age Restrictions
Adults and children (dosage varies)
Storage Guidelines
Store at room temperature.
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Assurans FAQ

Can I take Assurans if I have high blood pressure?

Assurans may be used by individuals with controlled hypertension, but severe uncontrolled blood pressure is a contraindication. A prescriber should assess cardiovascular stability before initiating therapy.

Does alcohol affect how Assurans works?

Moderate alcohol intake generally does not interfere with the medication’s effectiveness, but excessive drinking can increase the likelihood of dizziness and hypotension. It is advisable to limit alcohol consumption when planning sexual activity.

What should I do if I experience a prolonged erection?

A prolonged erection lasting more than four hours (priapism) is a medical emergency. Seek immediate medical attention to prevent permanent tissue damage.

Are there any visual side effects I should watch for?

Rarely, sildenafil can cause transient visual disturbances such as a blue-tinted hue or blurred vision. Sudden vision loss requires urgent evaluation.

Can I take Assurans with my cholesterol medication?

Most statins do not have a clinically significant interaction with sildenafil. However, certain cholesterol-lowering agents that affect CYP3A4 (e.g., rosuvastatin) may warrant monitoring; discuss all current medicines with your prescriber.

Is it safe to take Assurans daily?

Assurans is intended for use as needed, not on a fixed daily schedule. Daily dosing should only be considered under direct medical supervision.

How does a high-fat meal change the medication’s effect?

A high-fat meal can delay absorption, postponing the onset of erection by up to an hour. Taking the tablet on an empty stomach or with a light meal may provide a quicker response.

What are the storage requirements for Assurans tablets?

Keep the tablets at room temperature, away from moisture and direct sunlight, and store them out of reach of children.

Do I need any special tests before starting Assurans?

Routine baseline assessments such as blood pressure measurement and a review of cardiovascular history are standard. Specific laboratory tests are not required solely for sildenafil initiation unless indicated by comorbid conditions.

What is Assurans?

Assurans is a prescription-only pill that contains the active ingredient sildenafil. It belongs to the therapeutic class of erectile dysfunction (ED) treatments and is formulated as a 20 mg tablet. In the United Kingdom the medication is regulated by the Medicines and Healthcare products Regulatory Agency (MHRA) and may only be dispensed with a prescription from a qualified prescriber.

How Assurans Works in the Body

Sildenafil belongs to a group of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. By blocking the PDE5 enzyme, the medication prevents the breakdown of cyclic guanosine monophosphate (cGMP) within the smooth muscle cells of the penile vasculature. Elevated cGMP levels cause relaxation of these muscles, allowing increased blood flow into the corpus cavernosum when sexual stimulation triggers nitric-oxide release. The result is the ability to achieve and maintain an erection suitable for sexual activity. The onset of action typically occurs within 30-60 minutes after ingestion, with the effect lasting up to several hours.

Conditions Treated by Assurans

Assurans is approved in the UK for the treatment of erectile dysfunction in adult males. The medication helps men who experience difficulty attaining or sustaining an erection sufficient for satisfactory sexual performance. It is not indicated for use in women, children, or individuals without a diagnosis of ED.

Who Should Not Use Assurans?

Absolute Contraindications

  • Known hypersensitivity to sildenafil or any of the tablet’s inactive ingredients.
  • Concurrent use of any nitrate medication (e.g., nitroglycerin, isosorbide dinitrate) because the combination can cause a dangerous fall in blood pressure.
  • Severe uncontrolled hypertension (systolic > 180 mmHg or diastolic > 100 mmHg).

Relative Contraindications

  • Significant cardiovascular disease (e.g., recent myocardial infarction, unstable angina, severe heart failure).
  • History of non-arteritic anterior ischemic optic neuropathy (NAION) or other serious ocular conditions.
  • Severe hepatic impairment or moderate to severe renal impairment; dose adjustment may be required.
  • Use in pregnancy or lactation is not recommended, as safety has not been established.

Patients with any of the above conditions should discuss alternatives with their prescriber.

Safety Profile: Side Effects and Interactions

Common Side Effects

  • Headache - frequently reported.
  • Facial flushing - a warm sensation in the face or neck.
  • Indigestion or dyspepsia - may improve by taking the tablet with food.
  • Nasal congestion - a blocked or runny nose.

These effects are usually mild and transient, often subsiding without medical intervention.

Serious Adverse Events

  • Sudden vision loss or a blue-tinted visual disturbance may signal NAION; seek immediate medical attention.
  • Prolonged or painful erections lasting more than four hours (priapism) require urgent care to prevent tissue damage.
  • Severe hypotension, especially when combined with nitrates, can cause dizziness, fainting, or shock.

Drug Interactions

  • Nitrates (any formulation) - contraindicated due to the risk of marked hypotension.
  • Alpha-blockers - may enhance blood-pressure-lowering effects; use only under close medical supervision.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin, ritonavir) - can increase sildenafil plasma concentrations, potentially intensifying side effects.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine) - may reduce effectiveness.

Food and Lifestyle Interactions

  • A high-fat meal can delay the onset of action by up to an hour; taking the tablet on an empty stomach or with a light meal may provide more predictable timing.
  • Moderate alcohol consumption is generally tolerated, but excessive intake may increase the risk of dizziness and hypotension.
  • Driving or operating machinery is permissible once the individual feels stable; avoid these activities if experiencing side effects such as dizziness or visual changes.

Patients should disclose all medications, supplements, and herbal products to their healthcare provider before starting Assurans.

How to Take Assurans

  • Standard dosing: One 20 mg tablet taken orally as needed, approximately 30 minutes before anticipated sexual activity. Do not exceed one tablet within a 24-hour period.
  • Administration details: Swallow the tablet whole with a glass of water. It may be taken with or without food, but be aware that a heavy, fatty meal can delay its effect.
  • Missed dose: If the planned activity does not occur, the tablet can be discarded; do not take an additional dose later to “make up” for the missed one.
  • Overdose: Symptoms may include pronounced headache, flushing, low blood pressure, or prolonged erection. Seek emergency medical care; treatment is supportive, and no specific antidote is required.
  • Discontinuation: The medication does not require tapering. Stopping use should be discussed with a prescriber, particularly if underlying health conditions are present.

Because individual response varies, the prescriber may adjust the regimen based on efficacy and tolerability.

Storage and Handling

  • Store Assurans tablets at room temperature (15-25 °C) away from excess moisture and direct sunlight.
  • Keep the medication out of reach of children and pets.
  • Do not use the tablets after the expiry date printed on the package; dispose of any leftover tablets according to local pharmacy take-back schemes or the instructions on the label.

Medication-Specific Glossary

Phosphodiesterase type 5 (PDE5) inhibitor
A class of drugs that block the PDE5 enzyme, thereby enhancing the nitric-oxide-cGMP pathway to promote penile erection.
cGMP (cyclic guanosine monophosphate)
A second messenger molecule that induces smooth-muscle relaxation in the corpus cavernosum, facilitating increased blood flow.
Peak plasma concentration
The highest level of sildenafil in the bloodstream after a dose, usually reached within 30-60 minutes when taken orally.

Medical Disclaimer

This article provides educational information about Assurans and is not a substitute for professional medical advice. Treatment decisions, including use for unapproved indications, must be made under the guidance of a qualified healthcare provider. The content is intended for informational purposes and does not constitute medical recommendations. Always consult a physician before starting, stopping, or changing any medication regimen.

Information for Assurans is sourced from established medical standards and updated frequently. It is provided for general guidance and should be confirmed with a healthcare professional before use.
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