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Antabuse Medication Information Leaflet

Common Use

Antabuse is commonly used in the treatment of alcohol dependence. It is used as a deterrent to drinking alcohol by causing unpleasant side effects such as nausea, vomiting, and flushing when alcohol is consumed.

Classification

Antabuse is classified as an alcohol antagonist. It works by interfering with the breakdown of alcohol in the body, leading to the unpleasant reactions when alcohol is consumed.

Generic Ingredient

The generic ingredient of Antabuse is disulfiram. It is available in the UK under the same name and as generic versions.

Certification Information

Antabuse (disulfiram) is approved for use in the treatment of alcohol dependence in the UK and in several other countries around the world.

Known Alternatives in UK

In the UK, there are alternative medications used in the treatment of alcohol dependence, such as acamprosate and naltrexone.

Clinical Use

Antabuse is used as part of a comprehensive treatment program for alcohol dependence, which may include counseling and support.

Spectrum Of Activity

Antabuse specifically targets alcohol metabolism in the body, leading to its characteristic deterrent effect on alcohol consumption.

Drug interaction

It is important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Antabuse, as it can have interactions with certain substances, especially alcohol-containing products, and medications such as metronidazole, oral anticoagulants, phenytoin, and theophylline.

Dosage and Directions

The typical dosage of Antabuse is 500 mg per day, taken orally. It is important to follow the instructions of your healthcare provider regarding the dosage and administration of the medication.

Contraindications and Precautions

Antabuse should not be used by individuals with severe heart disease, a history of psychosis, or hypersensitivity to disulfiram. Precautions should be taken in individuals with diabetes, hypothyroidism, epilepsy, and liver or kidney disease.

Possible side effect

Common side effects of Antabuse include drowsiness, acne, metallic taste, and impotence. More severe reactions can occur if alcohol is consumed while taking Antabuse, leading to symptoms such as respiratory difficulties, chest pain, and even heart attack in rare cases.

Missed dose and Overdose

If a dose of Antabuse is missed, it should be taken as soon as remembered, unless it is close to the next scheduled dose. Overdose can lead to symptoms such as nausea, vomiting, dizziness, confusion, and even loss of consciousness. In case of an overdose, seeking medical assistance is crucial.

Storage

Antabuse should be stored at room temperature, away from moisture and heat. It should be kept out of the reach of children and pets.

Known Non-standard Use

Antabuse is being researched for potential non-standard uses, but its primary function remains the treatment of alcohol dependence.

Special Cases

Special care should be taken when prescribing Antabuse to individuals with a history of psychiatric disorders, as it can exacerbate certain mental health conditions.

Patient Considerations

Patients should be educated about the potential consequences of drinking alcohol while taking Antabuse and should be supported in their efforts to abstain from alcohol consumption.

Breastfeeding and Pregnancy

It is important to consult a healthcare professional before using Antabuse during pregnancy or while breastfeeding, as the potential risks to the fetus or the nursing infant should be carefully assessed.

Possible Risks

Using Antabuse comes with the risk of severe reactions if alcohol is consumed, and precautions should be taken to avoid exposure to alcohol in various products and settings. It is important to use Antabuse only as prescribed by a healthcare provider and to follow the recommendations for alcohol avoidance.

Antabuse FAQ

How does Antabuse work?

Antabuse works by interfering with the body's ability to metabolize alcohol. It blocks the enzyme acetaldehyde dehydrogenase, causing a buildup of acetaldehyde in the body when alcohol is consumed. This leads to unpleasant symptoms such as flushing, vomiting, and headache, which act as a deterrent to drinking.

What are the side effects of Antabuse?

Common side effects of Antabuse include drowsiness, acne, headache, and metallic or garlic-like taste in the mouth. In rare cases, more severe side effects such as liver problems and allergic reactions may occur.

How long does Antabuse stay in your system?

Antabuse has a half-life of about 60 to 120 hours, meaning it can stay in the body for up to 2 weeks after the last dose. It is important to avoid alcohol during this time to prevent severe reactions.

Can I drink alcohol while taking Antabuse?

No, it is extremely important to avoid all forms of alcohol while taking Antabuse. Even small amounts of alcohol can trigger severe and potentially dangerous reactions.

Can Antabuse be used to treat drug addiction?

Antabuse is primarily used to treat alcohol dependence, but it has also been used experimentally to deter individuals from using certain drugs by causing unpleasant reactions when combined with the drug.

Is Antabuse safe for everyone?

Antabuse is not suitable for everyone, particularly those with severe heart disease, a history of psychosis, or allergic reactions to disulfiram. It should be used with caution in individuals with diabetes, hypothyroidism, or epilepsy.

What should I do if I miss a dose of Antabuse?

If you miss a dose of Antabuse, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the next one at the scheduled time. Do not double the dose to make up for a missed one.

How long does Antabuse take to work?

Antabuse starts to work within 1 to 2 hours after it is taken. However, its full effects in discouraging alcohol consumption may take several weeks to become apparent.

Can Antabuse be crushed or split?

No, Antabuse should not be crushed, chewed, or split. It should be taken whole with a full glass of water to ensure the correct dose is administered.

Are there any dietary restrictions while taking Antabuse?

While taking Antabuse, it is important to avoid all foods and products that contain alcohol, such as certain sauces, vinegars, and flavorings. Reading labels carefully and being mindful of potential alcohol content in everyday products is essential.

Can Antabuse cause disulfiram-like reactions with other substances?

Yes, certain medications, foods, and even some skincare products containing alcohol or propylene glycol can cause disulfiram-like reactions when used with Antabuse. It is important to inform healthcare providers of all medications and products being used to prevent interactions.

How is Antabuse prescribed?

Antabuse is typically prescribed in tablet form for oral administration. The dosage and duration of treatment are determined by a healthcare professional based on individual needs and medical history.

What are the signs of an Antabuse overdose?

Signs of an Antabuse overdose may include confusion, seizures, and severe dizziness. If an overdose is suspected, immediate medical attention should be sought.

Can Antabuse be used during pregnancy and breastfeeding?

Antabuse should not be used during pregnancy unless the potential benefits outweigh the risks. It is also not recommended during breastfeeding as disulfiram may be excreted in breast milk and could harm the nursing infant.

Is Antabuse addictive?

No, Antabuse is not considered to be addictive. However, it should only be used as prescribed and under the supervision of a healthcare professional.

Antabuse Purchasing Information

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