Mesalazine is an aminosalicylate medication that works by reducing inflammation directly within the bowel lining. It is the primary treatment for mild to moderate ulcerative colitis and is used for maintenance therapy. As a key ingredient in many cost-effective generic treatments, it remains a gold standard for IBS management. Our pharmacy ensures secure access to high-quality medications containing Mesalazine for consistent therapeutic results.
Mesalazine (also known as 5-ASA) belongs to a group of anti-inflammatory medicines that work inside the gut. It is used mainly to calm swelling in the lining of the large intestine. In the UK, mesalazine is found in products such as Asacol and several other tablets and suspensions.
The most common brand that contains mesalazine in the United Kingdom is Asacol. Asacol is available as coated tablets that release the active ingredient throughout the intestine. A generic version of mesalazine is also prescribed, often in the form of oral tablets or a liquid suspension for children. While Asacol is the recognisable brand name, the same active substance may appear under different manufacturers’ label, each offering the same therapeutic effect but with varied packaging and dosage strengths.
These conditions are usually diagnosed by a gastroenterology specialist, and mesalazine is part of the therapeutic options approved by the Medicines and Healthcare products Regulatory Agency (MHRA) for managing intestinal inflammation.
Mesalazine releases a small amount of anti-inflammatory compound directly onto the lining of the bowel. By dampening the body’s inflammatory response in that area, it lessens swelling, pain and the leaking of blood into the stool. The medicine starts to act within a few days, but full benefits may become evident after several weeks of regular use.
These effects are usually short-lived and disappear without medical intervention.
Although rare, some people may experience severe allergic reactions such as swelling of the face, lips or throat, difficulty breathing, or a sudden rash that spreads quickly. If any of these signs appear, seek emergency medical help straight away.
Mesalazine can interact with certain other medicines, such as:
Alcohol consumption does not usually affect mesalazine, but excessive drinking can worsen gastrointestinal symptoms. Always read the specific interaction list for the exact product you are using.
Store mesalazine tablets in a dry place away from direct sunlight and keep them out of reach of children. The medication is generally intended for short-term flare treatment or long-term maintenance, depending on the doctor’s plan. Because each formulation (e.g., Asacol tablets versus a generic suspension) may have its own instructions, follow the label that comes with your specific product. For detailed dosing, administration and any special notices, refer to the product’s own patient information leaflet.
Mesalazine: The active anti-inflammatory ingredient used to treat inflammation of the bowel.
5-ASA: Short for 5-amino-salicylic acid, the chemical family to which mesalazine belongs.
Ulcerative colitis: A chronic disease causing inflammation and ulcers in the lining of the colon.
Remission: A period when disease symptoms are minimal or absent.
MHRA: The UK regulator that ensures medicines are safe and effective for public use.
This article offers general educational information about mesalazine as an active substance used in various medicines. Its purpose is to help patients better understand the ingredient and the conditions it is used to treat. It is not a substitute for professional medical advice or for the specific instructions provided with individual products. Medicines containing mesalazine may differ in formulation, strength, and directions for use. Always consult the labeling of your particular medication and follow your healthcare provider’s guidance for complete information on proper use, dosage, and safety.
