Cycloserine is a specialised antibiotic used as a second-line treatment for tuberculosis when primary medications are ineffective or cannot be used. It works by interfering with the bacterial cell wall synthesis. As a vital part of multi-drug resistant therapy (MDR-TB), it is available in several trusted generic forms. Our pharmacy platform provides reliable access to treatments containing Cycloserine.
Cycloserine belongs to the class of antibiotics known as cyclic-lactam antibiotics. It works by interfering with the bacterial cell wall, helping the body clear certain infections. In the United Kingdom, cycloserine is listed on the Medicines and Healthcare products Regulatory Agency (MHRA) register as a prescription-only medicine for specific indications.
The primary product that contains cycloserine in the UK market is Scarend Silicone Gel. This gel is marketed as a silicone-based scar-care product that incorporates cycloserine as an active ingredient. It is available in a single-use tube (approximately 5 ml) and is sold under the Scarend brand name. Generic versions of the gel are not currently listed in the NHS catalogue, so Scarend remains the main source for patients seeking a cycloserine-containing topical formulation.
The gel is applied externally to mature scars and is intended for short-term use, typically a few weeks, depending on individual skin response.
Cycloserine is primarily used for the following conditions:
In the context of Scarend Silicone Gel, the cycloserine component is intended to support scar-remodelling rather than treat infection. The gel is applied directly to the scar surface, where the ingredient may help modulate local cellular activity.
Cycloserine stops bacteria from building a strong cell wall by blocking a key step in the synthesis of peptidoglycan, an essential component of the bacterial envelope. Without a sturdy wall, the bacteria become vulnerable and are cleared by the immune system. When used in a topical gel, the ingredient is believed to influence fibroblast activity, encouraging more organised collagen formation and potentially reducing scar thickness.
These reactions are generally short-lived and do not require medical intervention unless they persist.
If any of these symptoms develop, stop using the product and seek urgent medical attention.
For a complete list of possible interactions, refer to the specific product’s full prescribing information.
Store Scarend Silicone Gel in a cool, dry place away from direct sunlight. Keep the tube tightly sealed to prevent contamination. The gel is intended for short-term, external use on mature scars; prolonged application beyond the recommended period may increase the chance of skin irritation. Remember that each product containing cycloserine may differ in concentration and formulation, so always follow the instructions printed on the packaging. For detailed usage, dosing, administration, refer to your specific medication's information.
Tuberculosis (TB): An infectious disease caused by the bacterium Mycobacterium tuberculosis, primarily affecting the lungs.
Multidrug-resistant TB (MDR-TB): A form of tuberculosis that does not respond to at least isoniazid and rifampicin, the two most potent first-line anti-TB drugs.
Fibroblast: A type of cell in the skin that produces collagen and other fibers, playing a key role in wound healing and scar formation.
This article offers general educational information about cycloserine as an active substance used in various medicines. Its purpose is to help patients better understand the ingredient and the conditions it is used to treat. It is not a substitute for professional medical advice or for the specific instructions provided with individual products. Medicines containing cycloserine may differ in formulation, strength, and directions for use. Always consult the labeling of your particular medication and follow your healthcare provider’s guidance for complete information on proper use, dosage, and safety.
